The TAAR5 agonist α-NETA causes dyskinesia in mice.

Animals Male Mice, Inbred C57BL Motor Activity / drug effects Naphthalenes Quaternary Ammonium Compounds Receptors, G-Protein-Coupled / agonists Tardive Dyskinesia / chemically induced
Dyskinesia TAAR5 Tardive dyskinesia Trace amine-associated receptors Trace amines α-NETA

Journal

Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130

Informations de publication

Date de publication:
21 06 2019
Historique:
received: 06 03 2019
revised: 02 04 2019
accepted: 09 04 2019
pubmed: 16 4 2019
medline: 6 2 2020
entrez: 16 4 2019
Statut: ppublish

Résumé

It is known that trace amine-associated receptor 5 (TAAR5) is expressed in various regions of the central nervous system. However, very limited information is available on the behavioral effects of TAAR5 activation and the TAAR5 functional role, in general. We studied the effect of TAAR5 agonist (2-(alpha-naphthoyl) ethyltrimethylammonium iodide) systemic administration on animal behavior. The study was performed on male C57BL/6 mice. It was observed that α-NETA in 10 mg/kg dose caused specific impairment of motor behavior, similar to the manifestations of tardive dyskinesia in humans. It can be assumed that trace amines and TAAR5 may be involved in the human tardive dyskinesia pathogenesis.

Identifiants

DOI: 10.1016/j.neulet.2019.04.028 PMID: 30986441
pubmed: 30986441
pii: S0304-3940(19)30262-9
doi: 10.1016/j.neulet.2019.04.028
pii:
doi:

Substances chimiques

Naphthalenes 0
Quaternary Ammonium Compounds 0
Receptors, G-Protein-Coupled 0
trace amine-associated receptor 5, mouse 0
2-naphthoylethyltrimethylammonium 31059-54-8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

208-211

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Aleksander A Aleksandrov (AA)

Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.

Nadezhda V Polyakova (NV)

Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.

Ekaterina P Vinogradova (EP)

Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.

Raul R Gainetdinov (RR)

Institute of Translational Biomedicine and Saint Petersburg University Hospital, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.

Veronika M Knyazeva (VM)

Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia. Electronic address: v.m.knyazeva@spbu.ru.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The TAAR5 agonist α-NETA causes dyskinesia in mice.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The TAAR5 agonist α-NETA causes dyskinesia in mice.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Activité motrice › The TAAR5 agonist α-NETA causes dyskinesia in mice.
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › The TAAR5 agonist α-NETA causes dyskinesia in mice.
questionsmedicales.fr › Composés chimiques organiques › Composés onium › Composés d'ammonium quaternaire › The TAAR5 agonist α-NETA causes dyskinesia in mice.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › The TAAR5 agonist α-NETA causes dyskinesia in mice.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Dyskinésies › Dyskinésie tardive › The TAAR5 agonist α-NETA causes dyskinesia in mice.