Effect of raw potato starch on the gut microbiome and metabolome in mice.
Gut microbiome
Potato starch
Propionic acid
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
15 Jul 2019
15 Jul 2019
Historique:
received:
04
03
2019
revised:
29
03
2019
accepted:
11
04
2019
pubmed:
16
4
2019
medline:
19
11
2019
entrez:
16
4
2019
Statut:
ppublish
Résumé
The gut microbiome plays a pivotal role in human health and is affected by various factors. To investigate the association between phenotypic and microbiota-related changes in the gut and a raw starch-based diet, we fed mice with different starch substitutes (corn, wheat, rice, and potato) for 16 weeks. The potato starch-fed group showed the lowest weight gain and fat tissue accumulation of all the groups, as well as the highest insulin sensitivity. Taxonomic analysis indicated that the proportions of Akkermansia, Rikenellaceae, and Sutterella showed the greatest increase in the ceca of mice fed raw potato starch. In addition, the gut microbiota of the raw potato starch group showed the highest carbohydrate and energy metabolism of all the groups, as confirmed by cecal metabolite analysis. The raw potato starch group also produced the highest propionic acid content. Our results showed that the differences in the digestibility of each starch, differences in the phenotype in terms of digestibility, and changes in intestinal microbiota were connected, and it was confirmed that potato starch, which had the lowest digestibility, caused the greatest difference in intestinal microbe composition and metabolism.
Identifiants
pubmed: 30986463
pii: S0141-8130(19)31641-1
doi: 10.1016/j.ijbiomac.2019.04.085
pii:
doi:
Substances chimiques
Starch
9005-25-8
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-43Informations de copyright
Copyright © 2019. Published by Elsevier B.V.