Epinephrine in Neonatal Resuscitation.
epinephrine
intramuscular
intraosseous
intravenous
newborn
resuscitation
Journal
Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936
Informations de publication
Date de publication:
02 Apr 2019
02 Apr 2019
Historique:
received:
01
03
2019
revised:
28
03
2019
accepted:
29
03
2019
entrez:
17
4
2019
pubmed:
17
4
2019
medline:
17
4
2019
Statut:
epublish
Résumé
Epinephrine is the only medication recommended by the International Liaison Committee on Resuscitation for use in newborn resuscitation. Strong evidence from large clinical trials is lacking owing to the infrequent use of epinephrine during neonatal resuscitation. Current recommendations are weak as they are extrapolated from animal models or pediatric and adult studies that do not adequately depict the transitioning circulation and fluid-filled lungs of the newborn in the delivery room. Many gaps in knowledge including the optimal dosing, best route and timing of epinephrine administration warrant further studies. Experiments on a well-established ovine model of perinatal asphyxial cardiac arrest closely mimicking the newborn infant provide important information that can guide future clinical trials.
Identifiants
pubmed: 30987062
pii: children6040051
doi: 10.3390/children6040051
pmc: PMC6518253
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NICHD NIH HHS
ID : R03 HD096299
Pays : United States
Organisme : National Institutes of Health
ID : HD096299
Organisme : National Institutes of Health
ID : HD072929
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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