Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease.

Alzheimer Disease / metabolism Amaryllidaceae / chemistry Amaryllidaceae Alkaloids / chemistry Blood-Brain Barrier / metabolism Glycogen Synthase Kinase 3 beta / metabolism Humans Ligands Models, Molecular Molecular Conformation Molecular Docking Simulation Molecular Structure Permeability Phenanthridines / chemistry Structure-Activity Relationship
Alzheimer’s disease Amaryllidaceae acetylcholinesterase butyrylcholinesterase docking studies glycogen synthase kinase-3β inhibition haemanthamine

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
03 Apr 2019
Historique:
received: 14 03 2019
revised: 28 03 2019
accepted: 01 04 2019
entrez: 17 4 2019
pubmed: 17 4 2019
medline: 8 8 2019
Statut: epublish

Résumé

Twelve derivatives

Identifiants

DOI: 10.3390/molecules24071307 PMID: 30987121 PMC: PMC6480460
pubmed: 30987121
pii: molecules24071307
doi: 10.3390/molecules24071307
pmc: PMC6480460
pii:
doi:

Substances chimiques

Amaryllidaceae Alkaloids 0
Ligands 0
Phenanthridines 0
hemanthamine 466-75-1
Glycogen Synthase Kinase 3 beta EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Univerzita Karlova v Praze
ID : GA UK Nr. 178518, SVV UK 260 412; 260 401; Progres/UK Q40 and Q42
Organisme : University Hospital, Hradec Králové
ID : 00179906
Organisme : European Union
ID : CZ.02.1.01/0.0/0.0/18_069/0010046

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Auteurs

Eliška Kohelová (E)

ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. kohelove@faf.cuni.cz.

Rozálie Peřinová (R)

ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. perinovr@faf.cuni.cz.

Negar Maafi (N)

ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. negarm@faf.cuni.cz.

Jan Korábečný (J)

Department of Toxicoloxy and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 05 Hradec Králové, Czech Republic. korabecny.jan1@gmail.com.
Department Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Králové, Czech Republic. korabecny.jan1@gmail.com.
ORCID: 0000-0001-6977-7596

Daniela Hulcová (D)

ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. hulcovd@faf.cuni.cz.
Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. hulcovd@faf.cuni.cz.

Jana Maříková (J)

Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. marikoj2@faf.cuni.cz.

Tomáš Kučera (T)

Department of Toxicoloxy and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 05 Hradec Králové, Czech Republic. tomas.kucera2@unob.cz.
ORCID: 0000-0001-6650-1738

Loreto Martínez González (L)

Centro de Investigaciones Biológicas-CSIC, Avenida Ramiro de Maeztu 9, 28040 Madrid, Spain. loretomg@cib.csic.es.

Martina Hrabinova (M)

Department of Toxicoloxy and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 05 Hradec Králové, Czech Republic. hrabinova@pmfhk.cz.

Katarina Vorčáková (K)

Deaprtment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10 Pardubice, Czech Republic. katarina.vorcakova@upce.cz.
ORCID: 0000-0001-6961-6151

Lucie Nováková (L)

Department of Analytical Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. novakoval@faf.cuni.cz.

Angela De Simone (A)

Department for Life Quality Studies, University of Bologna, Corso D'Augusto 237, 47921 Rimini, Italy. angela.desimone2@unibo.it.

Radim Havelek (R)

Department of Medicinal Biochemistry, Faculty of Medicine, Charles University, Zborovská 2089, 500 03 Hradec Králové, Czech Republic. havelekr@lfhk.cuni.cz.

Lucie Cahlíková (L)

ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. cahlikova@faf.cuni.cz.
ORCID: 0000-0002-1555-8870

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Asparagales › Amaryllidaceae › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Alcaloïdes des Amaryllidaceae › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Proline-directed protein kinases › Glycogen Synthase Kinase 3 › Glycogen synthase kinase 3 beta › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Phénomènes chimiques › Perméabilité › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Phénanthridines › Derivatives of the β-Crinane Amaryllidaceae...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Derivatives of the β-Crinane Amaryllidaceae...