Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry.
Body fluid
Drugs-of-abuse
ESI-MS
Quantitation
Wooden tips
Journal
Journal of food and drug analysis
ISSN: 2224-6614
Titre abrégé: J Food Drug Anal
Pays: China (Republic : 1949- )
ID NLM: 101630927
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
22
06
2018
revised:
13
09
2018
accepted:
13
09
2018
entrez:
17
4
2019
pubmed:
17
4
2019
medline:
6
5
2020
Statut:
ppublish
Résumé
Determination of drugs-of-abuse in body fluids of drug abusers is important for the law enforcement as well as the treatment and rehabilitation. In this study, wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS), a simple and cost-effective technique, was developed for rapid detection and quantitation of common drugs-of-abuse, including methamphetamine, methylenedioxymethamphetamine (MDMA), cocaine, heroin and tetrahydrocannabinol (THC), in urine and oral fluid, following our previous successful demonstration for rapid and sensitive detection of ketamine and nor-ketamine in urine and oral fluid by this technique. It was found that the limit-of-detection for methamphetamine could fully fulfill the cut-off value requirements of the international standards, and those of MDMA and cocaine could fulfill some of the requirements. The linear range, accuracy and precision for quantitation of the drugs were generally satisfactory, except for THC for which the analytical performance still needs to be improved. Analysis of one sample could typically be completed within minutes. These results indicated that WT-ESI-MS could be used for rapid screening of drugs-of-abuse in urine, oral fluid as well as other body fluids.
Identifiants
pubmed: 30987714
pii: j.jfda.2018.09.002
doi: 10.1016/j.jfda.2018.09.002
pmc: PMC9296206
doi:
Substances chimiques
Illicit Drugs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
428-438Informations de copyright
Copyright © 2018. Published by Elsevier Taiwan LLC.
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