Mobilization of Microbiota Commensals and Their Bacteriocins for Therapeutics.
Streptococcus salivarius
antibiotic multiresistance
bacteriocins
cell–cell communication
predation
probiotic
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
20
12
2018
revised:
12
03
2019
accepted:
19
03
2019
pubmed:
17
4
2019
medline:
1
7
2020
entrez:
17
4
2019
Statut:
ppublish
Résumé
With the specter of resurgence of pathogens due to the propagation of antibiotic-resistance genes, innovative antimicrobial strategies are needed. In this review, we summarize the beneficial aspects of bacteriocins, a set of miscellaneous peptide-based bacterium killers, compared with classical antibiotics, and emphasize their use in cocktails to curb the emergence of new resistance. We highlight that their prey spectrum, their molecular malleability, and their multiple modes of production might lead to specific and personalized treatments to prevent systemic disorders. Complementarily, we discuss how we might exploit prevailing bacterial commensals, such as Streptococcus salivarius, and deliberately mobilize their bacteriocin arsenal 'on site' to cure multiresistant infections or finely reshape the endogenous microbiota for prophylaxis purposes.
Identifiants
pubmed: 30987817
pii: S0966-842X(19)30071-X
doi: 10.1016/j.tim.2019.03.007
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacteriocins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
690-702Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.