Magnetic Resonance Imaging and Bioluminescence Imaging for Evaluating Tumor Burden in Orthotopic Colon Cancer.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
30
05
2018
accepted:
25
02
2019
entrez:
17
4
2019
pubmed:
17
4
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Quantifying tumor burden is important for following the natural history of orthotopic colon cancer and therapeutic efficacy. Bioluminescence imaging (BLI) is commonly used for such assessment and has both advantages and limitations. We compared BLI and magnetic resonance imaging (MRI) for quantifying orthotopic tumors in a mouse model of colon cancer. Among sequences tested, T2-based MRI imaging ranked best overall for colon cancer border delineation, contrast, and conspicuity. Longitudinal MRI detected tumor outside the colon, indistinguished by BLI. Colon tumor weights calculated from MRI in vivo correlated highly with tumor weights measured ex vivo whereas the BLI signal intensities correlated relatively poorly and this difference in correlations was highly significant. This suggests that MRI may more accurately assess tumor burden in longitudinal monitoring of orthotopic colon cancer in this model as well as in other models.
Identifiants
pubmed: 30988343
doi: 10.1038/s41598-019-42230-w
pii: 10.1038/s41598-019-42230-w
pmc: PMC6465293
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6100Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Références
J Neurooncol. 2018 Jan;136(1):63-71
pubmed: 29081036
Nat Rev Cancer. 2002 Jan;2(1):11-8
pubmed: 11902581
Mol Imaging. 2004 Oct;3(4):333-42
pubmed: 15802050
Cancer Res. 2009 Nov 15;69(22):8822-9
pubmed: 19861534
Int J Mol Imaging. 2013;2013:983534
pubmed: 23936648
Mol Imaging. 2009 Sep-Oct;8(5):245-53
pubmed: 19796602
Invest Radiol. 2013 Jun;48(6):413-21
pubmed: 23262791
Prostate. 2007 Jan 1;67(1):50-60
pubmed: 17031813
Cancer Res. 1988 Dec 1;48(23):6863-71
pubmed: 2846163
Am J Pathol. 2013 Feb;182(2):312-8
pubmed: 23219428
Cancer Res. 2007 Oct 1;67(19):9337-45
pubmed: 17909042
Int J Mol Imaging. 2014;2014:102702
pubmed: 24724022
Sci Rep. 2016 Oct 14;6:35230
pubmed: 27739457
Int J Mol Imaging. 2013;2013:287697
pubmed: 23936647
J Magn Reson Imaging. 2008 Jan;27(1):57-62
pubmed: 18058933
Nature. 2013 Sep 19;501(7467):346-54
pubmed: 24048067
Cancer Chemother Pharmacol. 2009 Oct;64(5):885-92
pubmed: 19214512
Radiology. 2005 Jun;235(3):950-8
pubmed: 15914480
J Biomed Opt. 2007 Mar-Apr;12(2):024007
pubmed: 17477722
Nat Med. 2013 Nov;19(11):1423-37
pubmed: 24202395
Multivariate Behav Res. 1980 Jul 1;15(3):335-52
pubmed: 26794186
Mol Imaging Biol. 2011 Dec;13(6):1114-23
pubmed: 20960234
Clin Exp Metastasis. 2017 Jan;34(1):51-62
pubmed: 27812769
Trends Mol Med. 2012 Mar;18(3):164-72
pubmed: 22321645
Neurosurgery. 2006 Feb;58(2):365-72; discussion 365-72
pubmed: 16462491
J Surg Res. 2013 Nov;185(1):143-51
pubmed: 23998649
Gut. 2013 Feb;62(2):259-71
pubmed: 22543158
Biotechniques. 2007 Jul;43(1 Suppl):7-13, 30
pubmed: 17936938
PLoS One. 2016 May 25;11(5):e0156162
pubmed: 27223614