Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses.
Animals
Cell Nucleus
/ metabolism
Cells, Cultured
Feces
/ virology
Gene Expression
Gene Expression Profiling
Gene Expression Regulation
Gene Knockout Techniques
Hepatocytes
/ immunology
Humans
Immunity, Innate
/ genetics
Interferon Regulatory Factor-1
/ genetics
Kinetics
Liver
/ virology
Mice
RNA Viruses
/ physiology
RNA, Small Interfering
Signal Transduction
/ genetics
Virus Replication
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
15
01
2019
accepted:
06
03
2019
pubmed:
17
4
2019
medline:
14
9
2019
entrez:
17
4
2019
Statut:
ppublish
Résumé
Current models of cell-intrinsic immunity to RNA viruses centre on virus-triggered inducible antiviral responses initiated by RIG-I-like receptors or Toll-like receptors that sense pathogen-associated molecular patterns, and signal downstream through interferon regulatory factors (IRFs), transcription factors that induce synthesis of type I and type III interferons
Identifiants
pubmed: 30988429
doi: 10.1038/s41564-019-0425-6
pii: 10.1038/s41564-019-0425-6
pmc: PMC6588457
mid: NIHMS1523237
doi:
Substances chimiques
Interferon Regulatory Factor-1
0
RNA, Small Interfering
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1096-1104Subventions
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI103083
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131685
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109965
Pays : United States
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