V348I mutation in UL23 gene of human herpesvirus 1 in a case of herpetic hepatitis and haemophagocytic lymphohistiocytosis.
Acyclovir
UL23 gene
haemophagocytic lymphohistiocytosis syndrome
herpetic hepatitis
human herpesvirus-1
Journal
New microbes and new infections
ISSN: 2052-2975
Titre abrégé: New Microbes New Infect
Pays: England
ID NLM: 101624750
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
31
12
2018
revised:
27
02
2019
accepted:
05
03
2019
entrez:
17
4
2019
pubmed:
17
4
2019
medline:
17
4
2019
Statut:
epublish
Résumé
We herein report the case of a young immunocompetent adult patient with a rapidly fatal haemophagocytic lymphohistiocytosis syndrome related to human herpesvirus 1 (HHV-1) infection, with herpetic hepatitis and persistent high-level viraemia despite treatment with acyclovir. Haemophagocytic lymphohistiocytosis was confirmed in the patient's spleen and bone marrow. HHV-1 DNA was extracted from whole blood and liver biopsy and the UL23 gene was sequenced. A V348I natural polymorphism of the TK protein was found in blood and liver specimens. Further studies are needed to investigate the role of this polymorphism in the development of systemic immune dysregulation.
Identifiants
pubmed: 30988955
doi: 10.1016/j.nmni.2019.100529
pii: S2052-2975(19)30025-3
pii: 100529
pmc: PMC6447736
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100529Références
J Infect Dis. 2000 Apr;181(4):1458-61
pubmed: 10762577
J Infect Dis. 2000 Jul;182(1):290-3
pubmed: 10882609
Pediatr Blood Cancer. 2007 Feb;48(2):124-31
pubmed: 16937360
Infection. 2010 Oct;38(5):423-6
pubmed: 20602145
Antimicrob Agents Chemother. 2010 Dec;54(12):5004-11
pubmed: 20876378
Blood. 2011 Oct 13;118(15):4041-52
pubmed: 21828139
Lancet. 2014 Apr 26;383(9927):1503-1516
pubmed: 24290661
Int J Hematol Oncol Stem Cell Res. 2013;7(1):42-5
pubmed: 24505517
J Blood Med. 2014 Jun 12;5:69-86
pubmed: 24966707
PLoS One. 2015 Sep 25;10(9):e0136825
pubmed: 26407292
Pediatr Int. 2016 May;58(5):390-393
pubmed: 27076380
BMJ Case Rep. 2017 Mar 29;2017:
pubmed: 28356254
Intern Med. 2017 Nov 1;56(21):2919-2923
pubmed: 28924117
Front Immunol. 2017 Sep 07;8:1102
pubmed: 28936212
Curr Opin Allergy Clin Immunol. 2017 Dec;17(6):405-413
pubmed: 28957822
Front Immunol. 2018 Jan 08;8:1902
pubmed: 29358936
Clin Infect Dis. 1997 Jun;24(6):1191-4
pubmed: 9195081
J Med Virol. 1998 Oct;56(2):151-8
pubmed: 9746072