Transient activation of the UPR
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
08
11
2018
accepted:
25
02
2019
entrez:
17
4
2019
pubmed:
17
4
2019
medline:
6
5
2020
Statut:
epublish
Résumé
Somatic cells can be reprogrammed into pluripotent stem cells using the Yamanaka transcription factors. Reprogramming requires both epigenetic landscape reshaping and global remodeling of cell identity, structure, basic metabolic processes, and organelle form and function. We hypothesize that variable regulation of the proteostasis network and its influence upon the protein-folding environment within cells and their organelles is responsible for the low efficiency and stochasticity of reprogramming. We find that the unfolded protein response of the endoplasmic reticulum (UPR
Identifiants
pubmed: 30989118
doi: 10.1126/sciadv.aaw0025
pii: aaw0025
pmc: PMC6457941
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaaw0025Subventions
Organisme : NIA NIH HHS
ID : R01 AG042679
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA196884
Pays : United States
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