Beyond the tumour microenvironment.
immune system
microbiome
nervous system
tumour microenvironment
tumour organismal environment
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 11 2019
15 11 2019
Historique:
received:
16
12
2018
revised:
05
04
2019
accepted:
08
04
2019
pubmed:
17
4
2019
medline:
18
2
2020
entrez:
17
4
2019
Statut:
ppublish
Résumé
In contrast to the once dominant tumour-centric view of cancer, increasing attention is now being paid to the tumour microenvironment (TME), generally understood as the elements spatially located in the vicinity of the tumour. Thinking in terms of TME has proven extremely useful, in particular because it has helped identify and comprehend the role of nongenetic and noncell-intrinsic factors in cancer development. Yet some current approaches have led to a TME-centric view, which is no less problematic than the former tumour-centric vision of cancer, insofar as it tends to overlook the role of components located beyond the TME, in the 'tumour organismal environment' (TOE). In this minireview, we highlight the explanatory and therapeutic shortcomings of the TME-centric view and insist on the crucial importance of the TOE in cancer progression.
Identifiants
pubmed: 30989643
doi: 10.1002/ijc.32343
pmc: PMC6766895
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2611-2618Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
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