Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus.
Animals
Anti-Inflammatory Agents
/ pharmacology
Cell Differentiation
/ physiology
Cellular Senescence
/ physiology
Dentate Gyrus
/ cytology
Inflammation
/ metabolism
Mice
Mice, Transgenic
Minocycline
/ pharmacology
Mitosis
/ physiology
Neural Stem Cells
/ cytology
Neurogenesis
/ physiology
Phenotype
adult neurogenesis
aging
hippocampus
neural stem cells
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
27
07
2018
revised:
20
03
2019
accepted:
21
03
2019
pubmed:
17
4
2019
medline:
8
7
2020
entrez:
17
4
2019
Statut:
ppublish
Résumé
Adult neurogenesis persists in the hippocampus of most mammal species during postnatal and adult life, including humans, although it declines markedly with age. The mechanisms driving the age-dependent decline of hippocampal neurogenesis are yet not fully understood. The progressive loss of neural stem cells (NSCs) is a main factor, but the true neurogenic output depends initially on the actual number of activated NSCs in each given time point. Because the fraction of activated NSCs remains constant relative to the total population, the real number of activated NSCs declines in parallel to the total NSC pool. We investigated aging-associated changes in NSCs and found that there are at least two distinct populations of NSCs. An alpha type, which maintains the classic type-1 radial morphology and accounts for most of the overall NSC mitotic activity; and an omega type characterized by increased reactive-like morphological complexity and much lower probability of division even under a pro-activation challenge. Finally, our results suggest that alpha-type NSCs are able to transform into omega-type cells overtime and that this phenotypic and functional change might be facilitated by the chronic inflammation associated with aging.
Identifiants
pubmed: 30989815
doi: 10.1111/acel.12958
pmc: PMC6612636
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Minocycline
FYY3R43WGO
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12958Subventions
Organisme : Eusko Jaurlaritza
ID : PI-2016-0011
Pays : International
Organisme : Ministerio de Economía y Competitividad
ID : BFU2015-66689
Pays : International
Organisme : Ministerio de Economía y Competitividad
ID : RyC-2012-11137
Pays : International
Organisme : Ministerio de Economía y Competitividad
ID : SAF-2015-70866
Pays : International
Informations de copyright
© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Références
Proc Natl Acad Sci U S A. 2006 May 23;103(21):8233-8
pubmed: 16702546
Neuropsychopharmacology. 2006 Dec;31(12):2619-26
pubmed: 16823390
Neurobiol Aging. 2010 Jan;31(1):151-61
pubmed: 18455269
Curr Neuropharmacol. 2018 Mar 5;16(3):308-326
pubmed: 28901279
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15570-5
pubmed: 18832146
Stem Cells. 2016 Apr;34(4):997-1010
pubmed: 26729510
Science. 2018 Feb 9;359(6376):658-662
pubmed: 29439238
Science. 2003 Aug 8;301(5634):805-9
pubmed: 12907793
Neuron. 2014 Sep 3;83(5):1085-97
pubmed: 25189209
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11352-7
pubmed: 18682560
Behav Brain Res. 2013 Apr 1;242:17-24
pubmed: 23274840
Cell Stem Cell. 2011 May 6;8(5):566-79
pubmed: 21549330
Front Syst Neurosci. 2015 Jul 14;9:102
pubmed: 26236203
Neurobiol Aging. 2011 Oct;32(10):1906-14
pubmed: 20006411
Mol Cell Neurosci. 2003 Jul;23(3):373-82
pubmed: 12837622
Nature. 2008 Feb 21;451(7181):1004-7
pubmed: 18235445
Cell Stem Cell. 2015 May 7;16(5):488-503
pubmed: 25957904
Neuropathol Appl Neurobiol. 2016 Dec;42(7):621-638
pubmed: 27424496
Cell Stem Cell. 2018 Apr 5;22(4):589-599.e5
pubmed: 29625071
Nature. 2011 Aug 03;476(7361):458-61
pubmed: 21814201
Stem Cell Reports. 2016 Apr 12;6(4):552-565
pubmed: 27050949
Front Aging Neurosci. 2010 Jan 04;1:6
pubmed: 20552057
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17169-73
pubmed: 17940008
J Neurosci. 1996 Mar 15;16(6):2027-33
pubmed: 8604047
Eur J Neurosci. 2003 Nov;18(10):2769-78
pubmed: 14656326
J Comp Neurol. 2004 Feb 9;469(3):311-24
pubmed: 14730584
Cereb Cortex. 2018 Jul 1;28(7):2458-2478
pubmed: 29722804
Stem Cell Reports. 2014 Jun 26;3(1):73-84
pubmed: 25068123
PLoS One. 2010 Jan 29;5(1):e8809
pubmed: 20126454
Cell. 2013 Jun 6;153(6):1219-1227
pubmed: 23746839
Trends Neurosci. 2004 Aug;27(8):447-52
pubmed: 15271491
Development. 2014 Jan;141(1):83-90
pubmed: 24284211
Cell. 2011 Jun 24;145(7):1142-55
pubmed: 21664664
Nat Neurosci. 1999 Oct;2(10):894-7
pubmed: 10491610
Aging Cell. 2019 Aug;18(4):e12958
pubmed: 30989815
Nat Med. 2019 Apr;25(4):554-560
pubmed: 30911133
Nat Med. 1998 Nov;4(11):1313-7
pubmed: 9809557
Nature. 2002 Feb 28;415(6875):1030-4
pubmed: 11875571
Nature. 2018 Mar 15;555(7696):377-381
pubmed: 29513649
J Neurosci. 2001 Sep 15;21(18):7153-60
pubmed: 11549726
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17501-6
pubmed: 17088541
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13632-7
pubmed: 14581618
Cell Stem Cell. 2010 Jul 2;7(1):78-89
pubmed: 20621052
Nat Methods. 2014 Oct;11(10):982-4
pubmed: 25264773
Nature. 2012 Sep 6;489(7414):150-4
pubmed: 22842902
PLoS One. 2011 Apr 15;6(4):e17600
pubmed: 21525974
Development. 2018 Jan 8;145(1):
pubmed: 29229768