α-Tocopherol, but Not γ-Tocopherol, Attenuates the Expression of Selective Tumor Necrosis Factor-Alpha-Induced Genes in Primary Human Aortic Cell Lines.


Journal

Lipids
ISSN: 1558-9307
Titre abrégé: Lipids
Pays: United States
ID NLM: 0060450

Informations de publication

Date de publication:
05 2019
Historique:
received: 31 10 2018
revised: 12 03 2019
accepted: 29 03 2019
pubmed: 17 4 2019
medline: 22 1 2020
entrez: 17 4 2019
Statut: ppublish

Résumé

Of the antioxidant vitamin E isoforms, α-tocopherol (αT) and γ-tocopherol (γT) are the most abundant in the human diet, and αT is consumed from both natural and synthetic sources. αT and γT may differentially impact inflammation and influence cardiovascular outcomes, in part by modulating gene expression. The goal of this study was to compare the effects of natural αT, synthetic αT, and γT on gene expression in two human cell lines. Human aortic smooth muscle cells (HASMC) and endothelial cells (HAEC) were either: (1) treated with 25 μM tocopherols alone, or (2) pretreated with tocopherols prior to a pro-inflammatory cytokine (tumor necrosis factor-alpha, TNF-α) stimulation. The expression of atherosclerosis-related genes was measured using RT

Identifiants

pubmed: 30990908
doi: 10.1002/lipd.12149
doi:

Substances chimiques

Antioxidants 0
Tumor Necrosis Factor-alpha 0
gamma-Tocopherol 8EF1Z1238F
alpha-Tocopherol H4N855PNZ1

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

289-299

Informations de copyright

© 2019 AOCS.

Auteurs

Katherine M Ranard (KM)

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, 905 S. Goodwin Ave., Urbana, IL 61801, USA.

Matthew J Kuchan (MJ)

Abbott Nutrition, 3300 Stelzer Road, Columbus, OH, 43219, USA.

John W Erdman (JW)

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, 905 S. Goodwin Ave., Urbana, IL 61801, USA.
Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 905 S. Goodwin Ave., Urbana, IL 61801, USA.

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Classifications MeSH