α-Tocopherol, but Not γ-Tocopherol, Attenuates the Expression of Selective Tumor Necrosis Factor-Alpha-Induced Genes in Primary Human Aortic Cell Lines.
Antioxidants
/ administration & dosage
Aorta
/ cytology
Atherosclerosis
/ genetics
Cell Survival
/ drug effects
Cells, Cultured
Endothelial Cells
/ drug effects
Gene Expression Profiling
Humans
Muscle, Smooth
/ cytology
Tumor Necrosis Factor-alpha
/ administration & dosage
Up-Regulation
/ drug effects
alpha-Tocopherol
/ administration & dosage
gamma-Tocopherol
/ chemistry
Atherosclerosis
Gene expression
Tocopherols
Vitamin E
Journal
Lipids
ISSN: 1558-9307
Titre abrégé: Lipids
Pays: United States
ID NLM: 0060450
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
31
10
2018
revised:
12
03
2019
accepted:
29
03
2019
pubmed:
17
4
2019
medline:
22
1
2020
entrez:
17
4
2019
Statut:
ppublish
Résumé
Of the antioxidant vitamin E isoforms, α-tocopherol (αT) and γ-tocopherol (γT) are the most abundant in the human diet, and αT is consumed from both natural and synthetic sources. αT and γT may differentially impact inflammation and influence cardiovascular outcomes, in part by modulating gene expression. The goal of this study was to compare the effects of natural αT, synthetic αT, and γT on gene expression in two human cell lines. Human aortic smooth muscle cells (HASMC) and endothelial cells (HAEC) were either: (1) treated with 25 μM tocopherols alone, or (2) pretreated with tocopherols prior to a pro-inflammatory cytokine (tumor necrosis factor-alpha, TNF-α) stimulation. The expression of atherosclerosis-related genes was measured using RT
Substances chimiques
Antioxidants
0
Tumor Necrosis Factor-alpha
0
gamma-Tocopherol
8EF1Z1238F
alpha-Tocopherol
H4N855PNZ1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
289-299Informations de copyright
© 2019 AOCS.