Inhibition of African swine fever virus infection by genkwanin.

African Swine Fever / virology African Swine Fever Virus / drug effects Animals Antiviral Agents / pharmacology Apigenin / pharmacology Chlorocebus aethiops Flavones / pharmacology Swine Vero Cells Virus Internalization / drug effects Virus Release / drug effects
African swine fever virus Antiviral agent Flavonoid Genkwanin Tubulin

Journal

Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699

Informations de publication

Date de publication:
07 2019
Historique:
received: 13 03 2019
revised: 08 04 2019
accepted: 11 04 2019
pubmed: 17 4 2019
medline: 15 5 2020
entrez: 17 4 2019
Statut: ppublish

Résumé

African swine fever virus (ASFV) is the causative agent of an economically important disease of pigs for which no effective vaccines or antiviral drugs are available. Recent outbreaks in EU countries and China have highlighted the critical role of antiviral research in combating this disease. We have previously shown that apigenin, a naturally occurring plant flavone, possesses significant anti-ASFV activity. However, apigenin is practically insoluble in highly polar solvents and it occurs typically in derivative forms in plants. Here we screened several commercially available apigenin derivatives for their ability to inhibit ASFV Ba71V strain in Vero cells. Among them, genkwanin showed significant inhibition of ASFV, reducing viral titer from 6.5 ± 0.1 to 4.75 ± 0.25 log TCID/ml in a dose-dependent manner (IC

Identifiants

DOI: 10.1016/j.antiviral.2019.04.008 PMID: 30991087
pubmed: 30991087
pii: S0166-3542(19)30148-2
doi: 10.1016/j.antiviral.2019.04.008
pii:
doi:

Substances chimiques

Antiviral Agents 0
Flavones 0
genkwanin 5K3I5D6B2B
Apigenin 7V515PI7F6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

78-82

Informations de copyright

Copyright © 2019. Published by Elsevier B.V.

Auteurs

Astghik Hakobyan (A)

Group of Antiviral Defense Mechanisms, Institute of Molecular of Biology of NAS, 0014, Yerevan, Armenia.

Erik Arabyan (E)

Group of Antiviral Defense Mechanisms, Institute of Molecular of Biology of NAS, 0014, Yerevan, Armenia.

Armen Kotsinyan (A)

Group of Antiviral Defense Mechanisms, Institute of Molecular of Biology of NAS, 0014, Yerevan, Armenia.

Zaven Karalyan (Z)

Laboratory of Cell Biology and Virology, Institute of Molecular of Biology of NAS, 0014, Yerevan, Armenia.

Harutyun Sahakyan (H)

Laboratory of Computational Modeling of Biological Processes, Institute of Molecular Biology of NAS, 0014, Yerevan, Armenia.

Vahram Arakelov (V)

Russian-Armenian (Slavonic) University, 0051, Yerevan, Armenia.

Karen Nazaryan (K)

Laboratory of Computational Modeling of Biological Processes, Institute of Molecular Biology of NAS, 0014, Yerevan, Armenia.

Fernando Ferreira (F)

Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.

Hovakim Zakaryan (H)

Group of Antiviral Defense Mechanisms, Institute of Molecular of Biology of NAS, 0014, Yerevan, Armenia. Electronic address: h_zakaryan@mb.sci.am.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Maladies de l'animal › Maladies des porcs › Peste porcine africaine › Inhibition of African swine fever virus...
questionsmedicales.fr › Virus › Virus à ADN › Asfarviridae › Virus de la peste porcine africaine › Inhibition of African swine fever virus...
questionsmedicales.fr › Eucaryotes › Animaux › Inhibition of African swine fever virus...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Inhibition of African swine fever virus...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavones › Apigénine › Inhibition of African swine fever virus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Inhibition of African swine fever virus...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavones › Inhibition of African swine fever virus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Inhibition of African swine fever virus...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › Inhibition of African swine fever virus...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Pénétration virale › Inhibition of African swine fever virus...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Libération de particules virales › Inhibition of African swine fever virus...