Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling.
Hedgehog signaling pathway
Sonic Hedgehog (Shh)
cancer
cell fate
cell receptor
cell signaling
cytoskeletal remodeling
endocytosis
kinome profiling
noncanonical morphogen signaling
signal transduction
signaling
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
21 06 2019
21 06 2019
Historique:
received:
14
02
2019
revised:
10
04
2019
pubmed:
18
4
2019
medline:
4
3
2020
entrez:
18
4
2019
Statut:
ppublish
Résumé
Hedgehog proteins are pivotal morphogens acting through a canonical pathway involving first activation of ligand binding to Patched followed by alleviation of Smoothened receptor inhibition, leading to activation of Gli transcription factors. Noncanonical Hedgehog signaling remains poorly characterized but is thought to be mainly dependent on Smoothened. However, Smoothened inhibitors have yielded only partial success in combating Hedgehog signal transduction-dependent cancer, suggesting that noncanonical Smoothened-independent pathways also are clinically relevant. Moreover, several Smoothened-dependent effects (
Identifiants
pubmed: 30992365
pii: S0021-9258(20)34711-6
doi: 10.1074/jbc.RA119.007956
pmc: PMC6597826
doi:
Substances chimiques
Hedgehog Proteins
0
Smo protein, mouse
0
Smoothened Receptor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9787-9798Informations de copyright
© 2019 Faria et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest with the contents of this article.
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