Structure Elucidation of Macrolide Antibiotics Using MS
Anti-Bacterial Agents
/ chemistry
Deuterium
/ chemistry
Erythromycin
/ analogs & derivatives
Josamycin
/ analogs & derivatives
Leucomycins
/ chemistry
Macrolides
/ chemistry
Oleandomycin
/ analogs & derivatives
Spectrometry, Mass, Electrospray Ionization
/ methods
Spiramycin
/ analogs & derivatives
Tylosin
/ analogs & derivatives
Water
/ chemistry
Macrolide antibiotics, Multilevel fragmentation, Structure elucidation
Journal
Journal of the American Society for Mass Spectrometry
ISSN: 1879-1123
Titre abrégé: J Am Soc Mass Spectrom
Pays: United States
ID NLM: 9010412
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
17
12
2018
accepted:
22
03
2019
revised:
28
02
2019
pubmed:
18
4
2019
medline:
7
1
2020
entrez:
18
4
2019
Statut:
ppublish
Résumé
The 14- and 16-membered macrolide antibiotics are an important structural class. Ubiquitously produced by a number of bacterial strains, namely actinomycetes, purification and structure elucidation of the wide array of analogs is challenging, both for discovery efforts and methodologies to monitor for byproducts, metabolites, and contaminants. Collision-induced dissociation mass spectrometry offers an attractive solution, enabling characterization of mixtures, and providing a wealth of structural information. However, interpretation of these spectra can be difficult. We present a study of 14- and 16-membered macrolide antibiotics, including MS
Identifiants
pubmed: 30993640
doi: 10.1007/s13361-019-02210-w
pii: 10.1007/s13361-019-02210-w
doi:
Substances chimiques
Anti-Bacterial Agents
0
Leucomycins
0
Macrolides
0
Water
059QF0KO0R
Erythromycin
63937KV33D
Spiramycin
8025-81-8
Deuterium
AR09D82C7G
Josamycin
HV13HFS217
Oleandomycin
P8ZQ646136
Tylosin
YEF4JXN031
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1464-1480Subventions
Organisme : Directorate for Mathematical and Physical Sciences
ID : 1518379
Organisme : Alfred P. Sloan Foundation
ID : none
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