Heterologous Prime-Boost Enhances the Antitumor Immune Response Elicited by Plant-Virus-Based Cancer Vaccine.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
24 04 2019
24 04 2019
Historique:
pubmed:
18
4
2019
medline:
24
6
2020
entrez:
18
4
2019
Statut:
ppublish
Résumé
New cancer vaccine strategies are required to vanquish the self-tolerance and elicit robust immune responses against tumor-associated antigens and/or neoantigens. Contemporary approaches in nanomedicine center on the use of a single nanocarrier modified with multiple copies of multiple different functional domains, e.g., epitopes for vaccines. Therefore, we set out to develop a combinatorial approach toward the next-generation concept of epitope delivery: a prime-boost strategy in which the same epitope is delivered using different nanocarriers. We tested this concept in the setting of HER2
Identifiants
pubmed: 30995022
doi: 10.1021/jacs.9b01523
pmc: PMC6957130
mid: NIHMS1066975
doi:
Substances chimiques
Cancer Vaccines
0
Receptor, ErbB-2
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6509-6518Subventions
Organisme : NCI NIH HHS
ID : R01 CA224605
Pays : United States
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