Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury.
lung injury
mechanical ventilation
preterm
proteomics
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
pubmed:
18
4
2019
medline:
24
4
2020
entrez:
18
4
2019
Statut:
ppublish
Résumé
The development of regional lung injury in the preterm lung is not well understood. This study aimed to characterize time-dependent and regionally specific injury patterns associated with early ventilation of the preterm lung using a mass spectrometry-based proteomic approach. Preterm lambs delivered at 124-127 days gestation received 15 or 90 minutes of mechanical ventilation (positive end-expiratory pressure = 8 cm H
Identifiants
pubmed: 30995072
doi: 10.1165/rcmb.2019-0084OC
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM