Oleuropein aglycone and hydroxytyrosol interfere differently with toxic Aβ
Acrylamide (PubChem CID: 6579)
Alzheimer's disease
Amyloid
Aβ(1-42) peptide
Congo Red (PubChem CID: 11313)
Hydroxythyrosol (PubChem: 82755) Dimethylsulfoxide (PubChem CID: 679)
Hydroxytyrosol
MTT (PubChem CID: 64965)
N,N-dimethylformamide (PubChem CID: 6228)
Oleuropein Aglycone (PubChem CID: 56842347)
Oleuropein aglycone
Sodium Dodecil Sulfate (PubChem CID: 3423265)
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
04
01
2019
revised:
08
04
2019
accepted:
10
04
2019
pubmed:
18
4
2019
medline:
7
8
2019
entrez:
18
4
2019
Statut:
ppublish
Résumé
Oleuropein aglycone (OleA), the most abundant polyphenol in extra virgin olive oil (EVOO), and Hydroxythyrosol (HT), the OleA main metabolite, have attracted our interest due to their multitarget effects, including the interference with amyloid aggregation path. However, the mechanistic details of their anti-amyloid effect are not known yet. We report here a broad biophysical approach and cell biology techniques that enabled us to characterize the different molecular mechanisms by which OleA and HT modulate the Aβ
Identifiants
pubmed: 30995514
pii: S0278-6915(19)30214-5
doi: 10.1016/j.fct.2019.04.015
pii:
doi:
Substances chimiques
Acetates
0
Amyloid beta-Peptides
0
Cyclopentane Monoterpenes
0
Peptide Fragments
0
Pyrans
0
amyloid beta-protein (1-42)
0
oleuropein aglycone
0
3,4-dihydroxyphenylethanol
10597-60-1
Phenylethyl Alcohol
ML9LGA7468
Types de publication
Journal Article
Langues
eng
Pagination
1-12Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.