TCR activation mimics CD127
CD127
Exhaustion
IL-7
Immunosuppression
PD-1
Sepsis
T-cell activation
Journal
Critical care (London, England)
ISSN: 1466-609X
Titre abrégé: Crit Care
Pays: England
ID NLM: 9801902
Informations de publication
Date de publication:
17 Apr 2019
17 Apr 2019
Historique:
received:
06
06
2018
accepted:
28
12
2018
entrez:
19
4
2019
pubmed:
19
4
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death. As interleukin-7 (IL-7) is currently tested in clinical trials to reverse these dysfunctions, it is important to evaluate the expression of its specific CD127 receptor on the T-cell surface of patients with septic shock. Moreover, the CD127 CD127 expression was followed at the protein and mRNA levels in patients with septic shock and healthy volunteers. CD127 In patients, neither CD127 expression nor its corresponding mRNA transcript level was modified compared with normal values. However, the percentage of CD127 The proportion of CD127
Sections du résumé
BACKGROUND
BACKGROUND
Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death. As interleukin-7 (IL-7) is currently tested in clinical trials to reverse these dysfunctions, it is important to evaluate the expression of its specific CD127 receptor on the T-cell surface of patients with septic shock. Moreover, the CD127
METHODS
METHODS
CD127 expression was followed at the protein and mRNA levels in patients with septic shock and healthy volunteers. CD127
RESULTS
RESULTS
In patients, neither CD127 expression nor its corresponding mRNA transcript level was modified compared with normal values. However, the percentage of CD127
CONCLUSIONS
CONCLUSIONS
The proportion of CD127
Identifiants
pubmed: 30995946
doi: 10.1186/s13054-018-2305-5
pii: 10.1186/s13054-018-2305-5
pmc: PMC6472012
doi:
Substances chimiques
IL7 protein, human
0
Interleukin-7
0
Interleukin-7 Receptor alpha Subunit
0
PDCD1 protein, human
0
Programmed Cell Death 1 Receptor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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