The Genome of C57BL/6J "Eve", the Mother of the Laboratory Mouse Genome Reference Strain.
C57BL/6J
Mus musculus domesticus
de novo genome assembly
laboratory mouse
long read sequencing
reference genomes
reproducibility
Journal
G3 (Bethesda, Md.)
ISSN: 2160-1836
Titre abrégé: G3 (Bethesda)
Pays: England
ID NLM: 101566598
Informations de publication
Date de publication:
05 06 2019
05 06 2019
Historique:
pubmed:
19
4
2019
medline:
31
12
2019
entrez:
19
4
2019
Statut:
epublish
Résumé
Isogenic laboratory mouse strains enhance reproducibility because individual animals are genetically identical. For the most widely used isogenic strain, C57BL/6, there exists a wealth of genetic, phenotypic, and genomic data, including a high-quality reference genome (GRCm38.p6). Now 20 years after the first release of the mouse reference genome, C57BL/6J mice are at least 26 inbreeding generations removed from GRCm38 and the strain is now maintained with periodic reintroduction of cryorecovered mice derived from a single breeder pair, aptly named Adam and Eve. To provide an update to the mouse reference genome that more accurately represents the genome of today's C57BL/6J mice, we took advantage of long read, short read, and optical mapping technologies to generate a
Identifiants
pubmed: 30996023
pii: g3.119.400071
doi: 10.1534/g3.119.400071
pmc: PMC6553538
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1795-1805Subventions
Organisme : NCI NIH HHS
ID : P30 CA034196
Pays : United States
Organisme : NIH HHS
ID : R24 OD021325
Pays : United States
Organisme : NIH HHS
ID : U42 OD010921
Pays : United States
Informations de copyright
Copyright © 2019 Sarsani et al.
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