PANDAS/PANS in childhood: Controversies and evidence.
Autoimmune
OCD
Paediatric
Psychiatric
Tics
Journal
Paediatrics & child health
ISSN: 1205-7088
Titre abrégé: Paediatr Child Health
Pays: England
ID NLM: 9815960
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
23
04
2018
accepted:
13
07
2018
entrez:
19
4
2019
pubmed:
19
4
2019
medline:
19
4
2019
Statut:
ppublish
Résumé
Since first defined in 1998, paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) and its later, broader iteration, paediatric acute-onset neuropsychiatric syndrome (PANS), have garnered significant attention and controversy. The role of streptococcal infection in children with explosive onset obsessive-compulsive disorder and new onset tics, the natural history of this entity, and the role of symptomatic and disease-modifying therapies, including antibiotics, immunotherapy, and psychoactive drugs, are all issues that have yet to be definitively addressed. While definitive proof of the autoimmune hypothesis of PANDAS is lacking, given the heightened attention to this entity and apparent rise in use of this diagnostic category, addressing questions around diagnosis, treatment, and etiology is imperative. In this paper, we review current working definitions of PANDAS/PANS, discuss published evidence for interventions related to this entity, and propose a clinical approach to children presenting with acute symptoms satisfying criteria for PANDAS/PANS.
Identifiants
pubmed: 30996598
doi: 10.1093/pch/pxy145
pii: pxy145
pmc: PMC6462125
doi:
Types de publication
Journal Article
Langues
eng
Pagination
85-91Références
Biol Psychiatry. 1999 Jun 15;45(12):1564-71
pubmed: 10376116
Lancet. 1999 Oct 2;354(9185):1153-8
pubmed: 10513708
Neurology. 2002 Jul 23;59(2):227-31
pubmed: 12136062
Pediatr Neurol. 2004 Feb;30(2):107-10
pubmed: 14984902
Pediatrics. 2004 Jun;113(6):e578-85
pubmed: 15173540
Biol Psychiatry. 2005 Apr 1;57(7):788-92
pubmed: 15820236
Pediatrics. 2005 Jul;116(1):56-60
pubmed: 15995031
Neurology. 2005 Dec 13;65(11):1701-7
pubmed: 16207842
J Neuroimmunol. 2006 Oct;179(1-2):173-9
pubmed: 16875742
J Am Acad Child Adolesc Psychiatry. 2006 Oct;45(10):1171-8
pubmed: 17003662
Pediatrics. 2008 Aug;122(2):273-8
pubmed: 18676543
Circulation. 2009 Mar 24;119(11):1541-51
pubmed: 19246689
J Am Acad Child Adolesc Psychiatry. 2011 Feb;50(2):108-118.e3
pubmed: 21241948
Neurology. 2011 Apr 26;76(17):1508-13
pubmed: 21411742
Int J Pediatr Otorhinolaryngol. 2011 Jun;75(6):872-3
pubmed: 21466900
Curr Psychiatry Rep. 2012 Jun;14(3):220-8
pubmed: 22477442
Clin Infect Dis. 2012 Nov 15;55(10):1279-82
pubmed: 23091044
Pediatr Infect Dis J. 2013 Aug;32(8):834-8
pubmed: 23518825
J Neuroimmunol. 2013 Nov 15;264(1-2):106-13
pubmed: 24080310
Int J Immunopathol Pharmacol. 2014 Jul-Sep;27(3):371-8
pubmed: 25280028
Behav Res Ther. 2015 Jan;64:15-23
pubmed: 25463245
JAMA Otolaryngol Head Neck Surg. 2015 Mar;141(3):272-5
pubmed: 25569020
J Child Adolesc Psychopharmacol. 2015 Feb;25(1):70-5
pubmed: 25658452
J Child Adolesc Psychopharmacol. 2015 Feb;25(1):65-9
pubmed: 25658609
J Child Adolesc Psychopharmacol. 2015 Feb;25(1):86-92
pubmed: 25658821
J Child Adolesc Psychopharmacol. 2015 Feb;25(1):26-30
pubmed: 25695941
J Child Adolesc Psychopharmacol. 2015 Feb;25(1):31-7
pubmed: 25695942
J Child Adolesc Psychopharmacol. 2015 Feb;25(1):38-47
pubmed: 25695943
J Pediatr Health Care. 2015 Sep-Oct;29(5):442-52
pubmed: 25895693
J Child Adolesc Psychopharmacol. 2015 May;25(4):337-43
pubmed: 25978743
Tremor Other Hyperkinet Mov (N Y). 2015 Jul 06;5:270
pubmed: 26196024
J Clin Psychiatry. 2016 Jul;77(7):e848-54
pubmed: 27464318
J Am Acad Child Adolesc Psychiatry. 2016 Oct;55(10):860-867.e2
pubmed: 27663941
Cytokine. 2017 Aug;96:49-53
pubmed: 28288328
J Child Adolesc Psychopharmacol. 2017 Sep;27(7):640-651
pubmed: 28358599
JAMA Psychiatry. 2017 Jul 1;74(7):740-746
pubmed: 28538981
J Child Adolesc Psychopharmacol. 2017 Sep;27(7):619-628
pubmed: 28696786
J Child Adolesc Psychopharmacol. 2017 Sep;27(7):629-639
pubmed: 28714753
J Child Adolesc Psychopharmacol. 2018 Mar;28(2):92-103
pubmed: 28832181
J Neuroimmunol. 2017 Nov 15;312:31-37
pubmed: 28919236
J Am Acad Child Adolesc Psychiatry. 2017 Nov;56(11):940-947.e1
pubmed: 29096776
JAMA. 1994 Dec 14;272(22):1788-91
pubmed: 7661914
Am J Psychiatry. 1998 Feb;155(2):264-71
pubmed: 9464208