Random-start ovarian stimulation with aromatase inhibitor for fertility preservation in women with Japanese breast cancer.
aromatase inhibitor
breast cancer
double ovarian stimulation
fertility preservation
random-start
Journal
Reproductive medicine and biology
ISSN: 1445-5781
Titre abrégé: Reprod Med Biol
Pays: Japan
ID NLM: 101213278
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
30
09
2018
revised:
05
11
2018
accepted:
09
12
2018
entrez:
19
4
2019
pubmed:
19
4
2019
medline:
19
4
2019
Statut:
epublish
Résumé
Fertility preservation is an important issue for young cancer patients. Random-start controlled ovarian stimulation and double ovarian stimulation have been proposed for efficient oocyte retrieval within the limited time before cancer therapy. We aimed to clarify the efficacy of these new protocols within the Japanese population. We performed a retrospective observational study at a multicenter from February 2012 to August 2017. The study entailed 50 cycles with 34 patients who underwent fertility preservation due to breast cancer. Follicular phase or luteal phase ovarian stimulation with aromatase inhibitor was performed. A second ovarian stimulation was started with or without waiting until the next menstruation. We measured the number of retrieved oocytes and cryopreserved oocytes/embryos, the ratio of mature oocytes, and the fertilization rate. The numbers of retrieved oocytes and frozen oocytes/embryos were not significantly different between follicular phase and luteal phase ovarian stimulation. The number of retrieved oocytes was not reduced at the second ovum pick up compared to the first ovum pick up in the double ovarian stimulation. Random-start controlled ovarian stimulation and double ovarian stimulation with aromatase inhibitor for breast cancer patients were effective protocols for retrieving a greater number of oocytes within the limited time.
Identifiants
pubmed: 30996680
doi: 10.1002/rmb2.12263
pii: RMB212263
pmc: PMC6452013
doi:
Types de publication
Journal Article
Langues
eng
Pagination
167-172Déclaration de conflit d'intérêts
Conflict of interest: The authors declare no conflict of interest. Human rights statements and informed consent: The study was approved by the Tokyo Medical and Dental University (M2000‐2036), Kameda Medical Center, and Kameda IVF Clinic Makuhari Review Board (17‐018). All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and its later amendments. Informed consent was obtained from all patients for being included in the study.
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