Discovery of Pyrido[3',2':5,6]thiopyrano[4,3-


Journal

ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073

Informations de publication

Date de publication:
11 Apr 2019
Historique:
received: 24 10 2018
accepted: 17 01 2019
entrez: 19 4 2019
pubmed: 19 4 2019
medline: 19 4 2019
Statut: epublish

Résumé

Protein kinases dysregulation is extremely common in cancer cells, and the development of new agents able to simultaneously target multiple kinase pathways involved in angiogenesis and tumor growth may offer several advantages in the treatment of cancer. Herein we report the discovery of new pyridothiopyranopyrimidine derivatives (

Identifiants

pubmed: 30996779
doi: 10.1021/acsmedchemlett.8b00499
pmc: PMC6466516
doi:

Types de publication

Journal Article

Langues

eng

Pagination

457-462

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Silvia Salerno (S)

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Elisabetta Barresi (E)

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Aída Nelly García-Argáez (AN)

Dipartimento di Scienze del Farmaco, Università di Padova, Via Marzolo 5, 35131 Padova, Italy.

Sabrina Taliani (S)

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Francesca Simorini (F)

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Giorgio Amendola (G)

DiSTABiF, Università della Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.

Stefano Tomassi (S)

DiSTABiF, Università della Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.

Sandro Cosconati (S)

DiSTABiF, Università della Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.

Ettore Novellino (E)

Dipartimento di Farmacia, Università di Napoli "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.

Federico Da Settimo (F)

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Anna Maria Marini (AM)

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Lisa Dalla Via (L)

Dipartimento di Scienze del Farmaco, Università di Padova, Via Marzolo 5, 35131 Padova, Italy.

Classifications MeSH