Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
11 Apr 2019
11 Apr 2019
Historique:
received:
26
10
2018
accepted:
07
12
2018
entrez:
19
4
2019
pubmed:
19
4
2019
medline:
19
4
2019
Statut:
epublish
Résumé
Small molecule inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the privileged 2-amino-4-phenylthiazole moiety in NC inhibition, here we conceived, synthesized, and tested
Identifiants
pubmed: 30996780
doi: 10.1021/acsmedchemlett.8b00506
pmc: PMC6466545
doi:
Types de publication
Journal Article
Langues
eng
Pagination
463-468Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
J Mol Biol. 2000 Aug 11;301(2):491-511
pubmed: 10926523
Nucleic Acids Res. 2001 Jul 1;29(13):E62-2
pubmed: 11433038
J Mol Biol. 2002 Mar 29;317(3):385-99
pubmed: 11922672
Biochimie. 2003 May;85(5):557-61
pubmed: 12763315
J Mol Biol. 2005 May 20;348(5):1113-26
pubmed: 15854648
Nucleic Acids Res. 2008 Aug;36(14):4745-53
pubmed: 18641038
J Mol Biol. 2008 Nov 28;383(5):1112-28
pubmed: 18773912
Biochemistry. 2008 Dec 9;47(49):13064-73
pubmed: 19006324
J Chem Inf Model. 2010 Apr 26;50(4):638-50
pubmed: 20201584
J Chem Inf Model. 2011 Feb 28;51(2):446-54
pubmed: 21171587
J Med Chem. 2012 Jun 14;55(11):4968-77
pubmed: 22587465
Virus Res. 2012 Nov;169(2):377-87
pubmed: 22634301
J Mol Biol. 2013 Jun 12;425(11):1982-1998
pubmed: 23485336
Virus Res. 2014 Nov 26;193:2-15
pubmed: 24907482
ACS Chem Biol. 2014 Sep 19;9(9):1950-5
pubmed: 24988251
J Vis Exp. 2015 Jan 19;(95):52474
pubmed: 25650789
Curr Top Microbiol Immunol. 2015;389:53-92
pubmed: 25749978
Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13555-60
pubmed: 26483503
J Chem Theory Comput. 2012 Sep 11;8(9):3314-21
pubmed: 26605738
Bioconjug Chem. 2016 Jan 20;27(1):247-56
pubmed: 26666402
Antiviral Res. 2016 Oct;134:216-225
pubmed: 27568924
Biochem Soc Trans. 2016 Oct 15;44(5):1427-1440
pubmed: 27911725
J Clin Lab Anal. 2018 Jan;32(1):null
pubmed: 28303602
ACS Chem Biol. 2018 Jan 19;13(1):253-266
pubmed: 29235845
Eur J Med Chem. 2018 Feb 10;145:154-164
pubmed: 29324338
Biopolymers. 1997 Mar;41(3):301-12
pubmed: 9057495
J Virol. 1997 Sep;71(9):6973-81
pubmed: 9261426
Science. 1998 Jan 16;279(5349):384-8
pubmed: 9430589