Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515.


Journal

ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073

Informations de publication

Date de publication:
11 Apr 2019
Historique:
received: 22 11 2018
accepted: 13 03 2019
entrez: 19 4 2019
pubmed: 19 4 2019
medline: 19 4 2019
Statut: epublish

Résumé

Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme involved in signaling and repair of DNA single strand breaks. PARP-1 employs NAD

Identifiants

pubmed: 30996792
doi: 10.1021/acsmedchemlett.8b00569
pmc: PMC6466814
doi:

Types de publication

Journal Article

Langues

eng

Pagination

534-538

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

Références

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1023-6
pubmed: 20045315
Trends Biochem Sci. 2010 Apr;35(4):208-19
pubmed: 20106667
Mol Aspects Med. 2013 Dec;34(6):1046-65
pubmed: 23290998
J Biomol Screen. 2014 Sep;19(8):1212-9
pubmed: 24916412
J Med Chem. 2015 Sep 10;58(17):6875-98
pubmed: 26222319
J Med Chem. 2016 Nov 10;59(21):9575-9598
pubmed: 27416328
Sci Transl Med. 2016 Oct 26;8(362):362ps17
pubmed: 27797957
J Med Chem. 2017 Feb 23;60(4):1262-1271
pubmed: 28001384
Science. 2017 Mar 17;355(6330):1152-1158
pubmed: 28302823
Cell Chem Biol. 2017 Sep 21;24(9):1101-1119
pubmed: 28938088
DNA Repair (Amst). 2018 Jun - Jul;66-67:24-29
pubmed: 29715575
Nat Rev Clin Oncol. 2018 Sep;15(9):564-576
pubmed: 29955114
P T. 2018 Sep;43(9):549-556
pubmed: 30186027
Curr Top Microbiol Immunol. 2019;420:211-231
pubmed: 30242511
Bioorg Med Chem Lett. 2018 Nov 1;28(20):3283-3289
pubmed: 30243589

Auteurs

Gianluca Papeo (G)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Paolo Orsini (P)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Nilla R Avanzi (NR)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Daniela Borghi (D)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Elena Casale (E)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Marina Ciomei (M)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Alessandra Cirla (A)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Viviana Desperati (V)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Daniele Donati (D)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Eduard R Felder (ER)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Arturo Galvani (A)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Marco Guanci (M)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Antonella Isacchi (A)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Helena Posteri (H)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Sonia Rainoldi (S)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Federico Riccardi-Sirtori (F)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Alessandra Scolaro (A)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Alessia Montagnoli (A)

Oncology, Nerviano Medical Sciences S.r.l., Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Classifications MeSH