Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
11 Apr 2019
11 Apr 2019
Historique:
received:
24
11
2018
accepted:
25
02
2019
entrez:
19
4
2019
pubmed:
19
4
2019
medline:
19
4
2019
Statut:
epublish
Résumé
The development of PPARα/γ dual or PPARα/γ/δ pan-agonists could represent an efficacious approach for a simultaneous pharmacological intervention on carbohydrate and lipid metabolism. Two series of new phenyldiazenyl fibrate derivatives of GL479, a previously reported PPARα/γ dual agonist, were synthesized and tested. Compound
Identifiants
pubmed: 30996794
doi: 10.1021/acsmedchemlett.8b00574
pmc: PMC6466826
doi:
Types de publication
Journal Article
Langues
eng
Pagination
545-551Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Mol Endocrinol. 2000 May;14(5):733-40
pubmed: 10809235
Mol Cell. 2000 Mar;5(3):545-55
pubmed: 10882139
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13919-24
pubmed: 11698662
Circulation. 2004 May 11;109(18):2197-202
pubmed: 15123532
Pharmacol Res. 2005 Feb;51(2):85-94
pubmed: 15629253
J Biol Chem. 2007 Jun 8;282(23):17314-24
pubmed: 17403688
Dig Liver Dis. 2008 Mar;40(3):200-5
pubmed: 18261709
Pharmacol Res. 2009 Sep;60(3):141-50
pubmed: 19646653
Am J Clin Nutr. 2010 Jan;91(1):267S-272S
pubmed: 19906796
Bioorg Med Chem Lett. 2012 Dec 15;22(24):7662-6
pubmed: 23102891
J Med Chem. 2013 Jan 10;56(1):60-72
pubmed: 23171045
Med Chem. 2014;10(1):59-65
pubmed: 23432317
Cardiovasc Diabetol. 2013 May 31;12:82
pubmed: 23721199
Physiol Rev. 2014 Jul;94(3):795-858
pubmed: 24987006
Br J Pharmacol. 2015 Dec;172(23):5512-22
pubmed: 25438608
Eur J Med Chem. 2015 Jan 27;90:583-94
pubmed: 25497132
Lipids Health Dis. 2015 Jul 08;14:68
pubmed: 26152344
J Struct Biol. 2015 Sep;191(3):332-40
pubmed: 26185032
J Am Soc Nephrol. 2016 Mar;27(3):666-76
pubmed: 26319242
Chem Biol Drug Des. 2016 Mar;87(3):467-71
pubmed: 26502898
Ann Intern Med. 2016 Sep 6;165(5):305-15
pubmed: 27322798
J Biomed Sci. 2016 Dec 3;23(1):87
pubmed: 27912756
Eur J Med Chem. 2017 Feb 15;127:379-397
pubmed: 28076827
J Am Chem Soc. 2017 Feb 8;139(5):1842-1855
pubmed: 28080040
Future Cardiol. 2017 May;13(3):259-278
pubmed: 28581332
J Med Chem. 2018 Mar 22;61(6):2246-2265
pubmed: 29446942
Bioorg Chem. 2018 Apr;77:548-567
pubmed: 29475164
Endocrinology. 1996 Nov;137(11):4706-12
pubmed: 8895337