Investigating the Anticancer Activity of Isatin/Dihydropyrazole Hybrids.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
11 Apr 2019
11 Apr 2019
Historique:
received:
29
11
2018
accepted:
17
12
2018
entrez:
19
4
2019
pubmed:
19
4
2019
medline:
19
4
2019
Statut:
epublish
Résumé
A series of isatin-dihydropyrazole hybrids have been synthesized in order to assess their potential as anticancer agents. In particular, 12 compounds were evaluated for their antiproliferative activity toward A549, IGR39, U87, MDA-MB-231, MCF-7, BT474, BxPC-3, SKOV-3, and H1299 cell lines, and human foreskin fibroblasts. Four compounds exhibited interesting antiproliferative activity and were further examined to determine their EC
Identifiants
pubmed: 30996798
doi: 10.1021/acsmedchemlett.8b00596
pmc: PMC6466827
doi:
Types de publication
Journal Article
Langues
eng
Pagination
571-576Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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