Role of cytokines in combinatorial immunotherapeutics of non-small cell lung cancer through systems perspective.
EGFR
IL-1RB
MAPK
NF-kB
NSCLC
systems biology
Journal
Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
21
09
2018
revised:
22
02
2019
accepted:
07
03
2019
pubmed:
19
4
2019
medline:
1
7
2020
entrez:
19
4
2019
Statut:
ppublish
Résumé
Lung cancer is the leading cause of deaths related to cancer and accounts for more than a million deaths per year. Various new strategies have been developed and adapted for treatment; still the survival for 5 years is just 16% in patients with non-small cell lung cancer (NSCLC). Most of these strategies to combat NSCLC whether it is a drug molecule or immunotherapy/vaccine candidate require a big cost and time. Integration of computational modeling with systems biology has opened new avenues for understanding complex cancer biology. Resolving the complex interactions of various pathways and their crosstalk leading to oncogenic changes could identify new therapeutic targets with lesser cost and time. Herein, this review provides an overview of various aspects of NSCLC along with available strategies for its cure concluding with our insight into how systems approach could serve as a therapeutic intervention dissecting the immunologic parameters and cross talk between various pathways involved.
Identifiants
pubmed: 30997737
doi: 10.1002/cam4.2112
pmc: PMC6536974
doi:
Substances chimiques
Antineoplastic Agents, Immunological
0
Cancer Vaccines
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1976-1995Informations de copyright
© 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
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