Physiological Responses of Jurkat Lymphocytes to Simulated Microgravity Conditions.
cell shape
cytoskeletal remodelling
lymphocytes
oxidative stress
simulated-microgravity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Apr 2019
17 Apr 2019
Historique:
received:
20
03
2019
revised:
11
04
2019
accepted:
13
04
2019
entrez:
20
4
2019
pubmed:
20
4
2019
medline:
17
8
2019
Statut:
epublish
Résumé
The presence of microgravity conditions deeply affects the human body functions at the systemic, organ and cellular levels. This study aimed to investigate the effects induced by simulated-microgravity on non-stimulated Jurkat lymphocytes, an immune cell phenotype considered as a biosensor of the body responses, in order to depict at the cellular level the effects of such a peculiar condition. Jurkat cells were grown at 1 g or on random positioning machine simulating microgravity. On these cells we performed: morphological, cell cycle and proliferation analyses using cytofluorimetric and staining protocols-intracellular Ca
Identifiants
pubmed: 30999563
pii: ijms20081892
doi: 10.3390/ijms20081892
pmc: PMC6515345
pii:
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Oxygen
S88TT14065
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Agenzia Spaziale Italiana
ID : 2014-018-R.O
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