S-Sulfocysteine Induces Seizure-Like Behaviors in Zebrafish.
NMDA receptors
S-Sulfocysteine
molybdenum cofactor
sulfite oxidase
zebrafish
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2019
2019
Historique:
received:
08
06
2018
accepted:
31
01
2019
entrez:
20
4
2019
pubmed:
20
4
2019
medline:
20
4
2019
Statut:
epublish
Résumé
Sulfite is a neurotoxin, which is detoxified by the molybdenum cofactor (Moco)-dependent enzyme sulfite oxidase (SOX). In humans, SOX deficiency causes the formation of the glutamate analog S-Sulfocysteine (SSC) resulting in a constant overstimulation of ionotropic glutamatergic receptors. Overstimulation leads to seizures, severe brain damage, and early childhood death. SOX deficiency may be caused either by a mutated
Identifiants
pubmed: 31001109
doi: 10.3389/fphar.2019.00122
pmc: PMC6454129
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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