Peritoneal Dialysis Vintage and Glucose Exposure but Not Peritonitis Episodes Drive Peritoneal Membrane Transformation During the First Years of PD.
EMT
TGF-ß
VEGF
glucose
glucose degradation products
peritoneal dialysis
peritoneal membrane
peritonitis
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2019
2019
Historique:
received:
07
01
2019
accepted:
14
03
2019
entrez:
20
4
2019
pubmed:
20
4
2019
medline:
20
4
2019
Statut:
epublish
Résumé
The impact of peritoneal dialysis (PD) associated peritonitis on peritoneal membrane integrity is incompletely understood. Children are particularly suited to address this question, since they are largely devoid of preexisting tissue damage and life-style related alterations. Within the International Peritoneal Biobank, 85 standardized parietal peritoneal tissue samples were obtained from 82 children on neutral pH PD fluids with low glucose degradation product (GDP) content. 37 patients had a history of peritonitis and 16 of the 37 had two or more episodes. Time interval between tissue sampling and the last peritonitis episode was 9 (4, 36) weeks. Tissue specimen underwent digital imaging and molecular analyses. Patients with and without peritonitis were on PD for 21.0 (12.0, 36.0) and 12.8 (7.3, 27.0) months (
Identifiants
pubmed: 31001140
doi: 10.3389/fphys.2019.00356
pmc: PMC6455046
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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