Application of an Artificial Neural Network in the Diagnosis of Chronic Lymphocytic Leukemia.
artificial neural network
biomarkers
chronic lymphocytic leukemia
diagnosis
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
04 Feb 2019
04 Feb 2019
Historique:
entrez:
20
4
2019
pubmed:
20
4
2019
medline:
20
4
2019
Statut:
epublish
Résumé
Introduction Chronic lymphocytic leukemia (CLL) is one of the most common types of leukemia, and the early diagnosis of patients coincides with their proper treatment and survival. If patients are diagnosed late or proper treatment is not applied, it may lead to harmful results. Several methods could be used for the diagnosis of leukemia; some of these include complete blood count (CBC), immunophenotyping, lymph node biopsy, chest X-ray, computerized tomography (CT) scan, and ultrasound. Most of these methods are time-consuming and an application of more than one method will result as intended. This acknowledgment stresses the necessity of rapid and proper diagnosis for leukemia based on clinical and medical findings, inasmuch as it was decided to apply the artificial neural network (ANN) in order to identify a molecular biomarker for rapid leukemia diagnosis from blood samples and evaluate its potential for the detection of cancer. Materials & methods The independent sample t-test was applied with the Statistical Package for the Social Sciences (SPSS; IBM Corp, Armonk, NY, US) software on the microarray gene expression data of Gene Expression Omnibus (GEO) datasets (GSE22529); 12 genes that had shown the highest differences (among parameters whose p-value was less than 0.01) were selected for further ANN analysis. The selected genes of 53 patients were applied to the training network algorithm, with a learning rate of 0.1. Results The results showed a high accuracy of the relationship between the output of the trained network and the test data. The area under the receiver operating characteristic (ROC) curve was 0.991, which provides proof of the precision and the relationship with identifying Gelsolin as a potential biomarker for this research. Conclusions With these results, it was concluded that the training process of the ANN could be applied to rapid CLL diagnosis and finding a potential biomarker. Besides, it is suggested that this method could be performed to diagnose other forms of cancer in order to get a rapid and reliable outcome.
Identifiants
pubmed: 31001458
doi: 10.7759/cureus.4004
pmc: PMC6450593
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e4004Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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