The Effect of Recombinant Human Erythropoietin on Bacterial Growth: A Dual-Edged Sword.
Anaemia
Bacteria
Chronic renal disease
Cytokines
Erythropoietin
Infection
Journal
Kidney diseases (Basel, Switzerland)
ISSN: 2296-9381
Titre abrégé: Kidney Dis (Basel)
Pays: Switzerland
ID NLM: 101658365
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
19
03
2018
accepted:
12
09
2018
entrez:
20
4
2019
pubmed:
20
4
2019
medline:
20
4
2019
Statut:
ppublish
Résumé
Hypererythropoietinemia is associated with common diseases like non-uremic anaemia where infection burden is high. Erythropoietin (EPO) is also given as therapy for anaemia associated with chronic kidney disease and cancer and in those who are at a higher risk of infections. EPO is known to have an effect on macrophages by which it helps in the growth of some intracellular pathogens. However, its direct role on bacterial growth is currently unknown. Here, we investigated the direct effect of recombinant human erythropoietin (rhuEPO) on the growth of pathogenic It appears that some pathogens can explore EPO to proliferate and growth of others are inhibited by the same. The consequence of such observation is a matter of widespread concern for future research.
Sections du résumé
BACKGROUND
BACKGROUND
Hypererythropoietinemia is associated with common diseases like non-uremic anaemia where infection burden is high. Erythropoietin (EPO) is also given as therapy for anaemia associated with chronic kidney disease and cancer and in those who are at a higher risk of infections. EPO is known to have an effect on macrophages by which it helps in the growth of some intracellular pathogens. However, its direct role on bacterial growth is currently unknown.
SUMMARY
CONCLUSIONS
Here, we investigated the direct effect of recombinant human erythropoietin (rhuEPO) on the growth of pathogenic
KEY MESSAGE
CONCLUSIONS
It appears that some pathogens can explore EPO to proliferate and growth of others are inhibited by the same. The consequence of such observation is a matter of widespread concern for future research.
Identifiants
pubmed: 31001539
doi: 10.1159/000493684
pii: kdd-0005-0081
pmc: PMC6468308
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
81-90Références
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