Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.

Black or African American / genetics Bayes Theorem Carcinoma, Ovarian Epithelial / genetics ErbB Receptors / genetics Female Genetic Association Studies Glucuronosyltransferase / genetics Humans Logistic Models Middle Aged Neoplasm Grading Ovarian Neoplasms / genetics Polymorphism, Single Nucleotide Receptors, Calcitriol / genetics Vitamin D / biosynthesis
African ancestry risk genetic association ovarian cancer vitamin D pathway

Journal

Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310

Informations de publication

Date de publication:
05 2019
Historique:
received: 31 07 2018
revised: 03 12 2018
accepted: 08 01 2019
pubmed: 20 4 2019
medline: 11 6 2020
entrez: 20 4 2019
Statut: ppublish

Résumé

An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. All subjects are of African ancestry (AA). Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI). We further evaluated statistical significance of selected SNPs using the Bayesian False Discovery Probability (BFDP). A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10

Identifiants

DOI: 10.1002/cam4.1996 PMID: 31001917 PMC: PMC6536963
pubmed: 31001917
doi: 10.1002/cam4.1996
pmc: PMC6536963
doi:

Substances chimiques

Receptors, Calcitriol 0
VDR protein, human 0
Vitamin D 1406-16-2
Glucuronosyltransferase EC 2.4.1.17
UGT2A1 protein, human EC 2.4.1.17
EGFR protein, human EC 2.7.10.1
ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2503-2513

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR000124
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C490/A10119
Pays : United Kingdom
Organisme : CIHR
ID : MOP‐86727
Pays : Canada
Organisme : NCI NIH HHS
ID : R01 CA122443
Pays : United States
Organisme : NIEHS NIH HHS
ID : Z01 ES049033
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA076292
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA115195
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA156735
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA071789
Pays : United States
Organisme : Cancer Research UK
ID : 10119
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R03 CA113148
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA159981
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148112
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058860
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA105009
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA142081
Pays : United States
Organisme : Cancer Research UK
ID : C490/A10124
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA126841
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD012393
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA112523
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA114343
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN025403
Pays : United States
Organisme : NIEHS NIH HHS
ID : Z01 ES044005
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA136393
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA080668
Pays : United States
Organisme : NIH HHS
ID : S10 OD025170
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA160669
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA176726
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States

Informations de copyright

© 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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Auteurs

Delores J Grant (DJ)

Department of Biological and Biomedical Sciences, Cancer Research Program, JLC-Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina.
ORCID: 0000-0001-8981-8930

Ani Manichaikul (A)

Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia.

Anthony J Alberg (AJ)

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.

Elisa V Bandera (EV)

Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.

Jill Barnholtz-Sloan (J)

Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
ORCID: 0000-0001-6190-9304

Melissa Bondy (M)

Cancer Prevention and Population Sciences Program, Baylor College of Medicine, Houston, Texas.

Michele L Cote (ML)

Department of Oncology and the Karmanos Cancer Institute Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, Michigan.

Ellen Funkhouser (E)

Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Patricia G Moorman (PG)

Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.

Lauren C Peres (LC)

Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia.

Edward S Peters (ES)

Epidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, Louisisana.

Ann G Schwartz (AG)

Department of Oncology and the Karmanos Cancer Institute Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, Michigan.

Paul D Terry (PD)

Department of Medicine, University of Tennessee Medical Center - Knoxville, Knoxville, Tennessee.

Xin-Qun Wang (XQ)

Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.

Temitope O Keku (TO)

Departments of Medicine and Nutrition, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Cathrine Hoyo (C)

Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina.

Andrew Berchuck (A)

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.

Dale P Sandler (DP)

Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.

Jack A Taylor (JA)

Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.

Katie M O'Brien (KM)

Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.

Digna R Velez Edwards (DR)

Vanderbilt Epidemiology Center, Center for Human Genetics Research, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee.

Todd L Edwards (TL)

Division of Epidemiology, Center for Human Genetics Research, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Alicia Beeghly-Fadiel (A)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee.

Nicolas Wentzensen (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Celeste Leigh Pearce (CL)

Department of Epidemiology, University of Michigan School of, Public Health, Ann Arbor, Michigan.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.

Anna H Wu (AH)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.

Alice S Whittemore (AS)

Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California.
Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California.

Valerie McGuire (V)

Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California.

Weiva Sieh (W)

Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

Joseph H Rothstein (JH)

Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

Francesmary Modugno (F)

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania.
Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

Roberta Ness (R)

The University of Texas School of Public Health, Houston, Texas.

Kirsten Moysich (K)

Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.
ORCID: 0000-0002-4678-2058

Mary Anne Rossing (MA)

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Department of Epidemiology, University of Washington, Seattle, Washington.

Jennifer A Doherty (JA)

Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.

Thomas A Sellers (TA)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.

Jennifer B Permuth-Way (JB)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
ORCID: 0000-0002-4726-9264

Alvaro N Monteiro (AN)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.

Douglas A Levine (DA)

Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Gynecologic Oncology, Laura and Isaac Pearlmutter Cancer Center, New York University Langone Medical Center, New York, New York.

Veronica Wendy Setiawan (VW)

University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.

Christopher A Haiman (CA)

University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.

Loic LeMarchand (L)

University of Hawaii Cancer Center, Honolulu, Hawaii.

Lynne R Wilkens (LR)

Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii.

Beth Y Karlan (BY)

Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Usha Menon (U)

MRC CTU at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.

Susan Ramus (S)

School of Women's and Children's Health, University of New South Wales, New South Wales, Australia.
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

Simon Gayther (S)

Center for Cancer Prevention and Translational Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.

Aleksandra Gentry-Maharaj (A)

MRC CTU at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.

Kathryn L Terry (KL)

Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard T. H. Chan School of Public Health, Boston, Massauchusetts.

Daniel W Cramer (DW)

Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard T. H. Chan School of Public Health, Boston, Massauchusetts.
ORCID: 0000-0002-8024-3066

Ellen L Goode (EL)

Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.

Melissa C Larson (MC)

Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.

Scott H Kaufmann (SH)

Departments of Medicine and Pharmacology, Mayo Clinic, Rochester, Minnesota.

Rikki Cannioto (R)

Cancer Pathology & Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York.

Kunle Odunsi (K)

Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York.

John L Etter (JL)

Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.

Ruea-Yea Huang (RY)

Center For Immunotherapy, Roswell Park Cancer Institute, Buffalo, New York.

Marcus Q Bernardini (MQ)

Division of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

Alicia A Tone (AA)

Division of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

Taymaa May (T)

Division of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

Marc T Goodman (MT)

Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Pamela J Thompson (PJ)

Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Michael E Carney (ME)

Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.

Shelley S Tworoger (SS)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Elizabeth M Poole (EM)

Biostatistics, Sanofi Genzyme, Boston, Massachusetts.

Diether Lambrechts (D)

Vesalius Research Center, VIB, Leuven, Belgium.
Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium.

Ignace Vergote (I)

Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.

Adriaan Vanderstichele (A)

Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.

Els Van Nieuwenhuysen (E)

Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.

Hoda Anton-Culver (H)

Department of Epidemiology, Director of Genetic Epidemiology Research Institute, Center for Cancer Genetics Research & Prevention, School of Medicine, University of California Irvine, Irvine, California.

Argyrios Ziogas (A)

Department of Epidemiology, University of California Irvine, Irvine, California.

James D Brenton (JD)

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.

Line Bjorge (L)

Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.

Helga B Salvensen (HB)

Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.

Lambertus A Kiemeney (LA)

Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, Netherlands.

Leon F A G Massuger (LFAG)

Department of Gynaecology, Radboud University Medical Center, Radboud Institute for Molecular Life sciences, Nijmegen, The Netherlands.

Tanja Pejovic (T)

Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon.
Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.

Amanda Bruegl (A)

Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon.
Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.

Melissa Moffitt (M)

Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon.
Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.

Linda Cook (L)

Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico.

Nhu D Le (ND)

Cancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

Angela Brooks-Wilson (A)

Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.

Linda E Kelemen (LE)

Hollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.

Paul D P Pharoah (PDP)

Strangeways Research laboratory, Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Honglin Song (H)

Strangeways Research Laboratory, Department of Oncology, University of Cambridge, Cambridge, UK.

Ian Campbell (I)

Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Victoria, Australia.
Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.

Diana Eccles (D)

Faculty of Medicine, University of Southampton, Southampton, UK.

Anna DeFazio (A)

Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.

Catherine J Kennedy (CJ)

Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.

Joellen M Schildkraut (JM)

Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Nord-Américains › Groupes de population aux États-Unis › Populations d'origine continentale › Noir ou Africain Américain › Evaluation of vitamin D biosynthesis and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Théorème de Bayes › Evaluation of vitamin D biosynthesis and...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Carcinome épithélial de l'ovaire › Evaluation of vitamin D biosynthesis and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Evaluation of vitamin D biosynthesis and...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Études d'associations génétiques › Evaluation of vitamin D biosynthesis and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Glucuronosyltransferase › Evaluation of vitamin D biosynthesis and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evaluation of vitamin D biosynthesis and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles logistiques › Evaluation of vitamin D biosynthesis and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Evaluation of vitamin D biosynthesis and...
questionsmedicales.fr › Diagnostic › Pronostic › Grading des tumeurs › Evaluation of vitamin D biosynthesis and...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Evaluation of vitamin D biosynthesis and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Evaluation of vitamin D biosynthesis and...
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