Regulation of matrix metalloproteinases 2 and 9 in corneal neovascularization.
Corneal Neovascularization
/ drug therapy
Humans
Matrix Metalloproteinase 2
/ chemistry
Matrix Metalloproteinase 9
/ chemistry
Matrix Metalloproteinase Inhibitors
/ chemistry
Ophthalmic Solutions
/ chemistry
Receptors, Notch
/ metabolism
Signal Transduction
Tissue Inhibitor of Metalloproteinases
/ metabolism
Vascular Endothelial Growth Factor A
/ metabolism
corneal neovascularization
matrix metalloproteinase 2
matrix metalloproteinase 9
vascular endothelial growth factor
Journal
Chemical biology & drug design
ISSN: 1747-0285
Titre abrégé: Chem Biol Drug Des
Pays: England
ID NLM: 101262549
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
20
01
2019
revised:
26
03
2019
accepted:
31
03
2019
pubmed:
20
4
2019
medline:
13
5
2021
entrez:
20
4
2019
Statut:
ppublish
Résumé
Corneal neovascularization (CNV), a pathological process of angiogenesis, can lead to serious consequences in the cornea. CNV is generally proved to associate with inflammation in the cornea closely, which is mainly elicited by the disruption of equilibrium between angiogenic and antiangiogenic factors. Angiogenic factors including vascular endothelial growth factors (VEGFs), basic fibroblast growth factors (bFGFs), and matrix metalloproteinases (MMPs) are vital factors in the formation of CNV. Especially VEGFs are convinced to be the core angiogenic factors in CNV, and MMPs are proved to exert dual effects on the process. Strikingly, matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) are determined to play key roles in the formation of CNV, while the mechanism is still vague. In this review, the latest researches are reviewed to discuss the role of MMP-2 and MMP-9 in CNV, respectively, and some inhibitors of them are presented. We hope to provide a new direction of drug research for CNV.
Substances chimiques
Matrix Metalloproteinase Inhibitors
0
Ophthalmic Solutions
0
Receptors, Notch
0
Tissue Inhibitor of Metalloproteinases
0
Vascular Endothelial Growth Factor A
0
Matrix Metalloproteinase 2
EC 3.4.24.24
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-492Informations de copyright
© 2020 John Wiley & Sons A/S.
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