Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial.

Cross-Over Studies Diabetes Mellitus, Type 2 / therapy Fasting / psychology Humans Male Middle Aged Risk Factors

Journal

Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860

Informations de publication

Date de publication:
05 2019
Historique:
received: 09 07 2018
accepted: 19 01 2019
pubmed: 20 4 2019
medline: 12 3 2020
entrez: 20 4 2019
Statut: ppublish

Résumé

This study aimed to assess the effects of 9-hour time-restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes. Fifteen men (age 55 ± 3 years, BMI 33.9 ± 0.8 kg/m TRF improved glucose tolerance as assessed by a reduction in glucose incremental area under the curve (P = 0.001) and fasting triglycerides (P = 0.003) on day 7 versus day 0. However, there were no mealtime by TRF interactions in any of the variables examined. There was also no effect of TRF on fasting and postprandial insulin, nonesterified fatty acids, or gastrointestinal hormones. Mean fasting glucose by continuous glucose monitor was lower in TRFe (P = 0.02) but not TRFd (P = 0.17) versus baseline, but there was no difference between TRF conditions. While only TRFe lowered mean fasting glucose, TRF improved glycemic responses to a test meal in men at risk for type 2 diabetes regardless of the clock time that TRF was initiated.

Identifiants

DOI: 10.1002/oby.22449 PMID: 31002478
pubmed: 31002478
doi: 10.1002/oby.22449
doi:

Banques de données

ClinicalTrials.gov
['NCT02633722']

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

724-732

Informations de copyright

© 2019 The Obesity Society.

Auteurs

Amy T Hutchison (AT)

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.
Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
ORCID: 0000-0002-6393-3671

Prashant Regmi (P)

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.
Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Emily N C Manoogian (ENC)

Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA.

Jason G Fleischer (JG)

Integrative Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA.

Gary A Wittert (GA)

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.
Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Satchidananda Panda (S)

Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA.

Leonie K Heilbronn (LK)

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.
Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Études croisées › Time-Restricted Feeding Improves Glucose...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Time-Restricted Feeding Improves Glucose...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Comportement alimentaire › Jeûne › Time-Restricted Feeding Improves Glucose...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Time-Restricted Feeding Improves Glucose...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Time-Restricted Feeding Improves Glucose...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Time-Restricted Feeding Improves Glucose...