Cue-alcohol associative learning in female rats.
Cue reactivity
Female rat
Low dose
Oral alcohol
Pavlovian conditioning
Journal
Alcohol (Fayetteville, N.Y.)
ISSN: 1873-6823
Titre abrégé: Alcohol
Pays: United States
ID NLM: 8502311
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
21
01
2019
revised:
14
03
2019
accepted:
19
03
2019
pubmed:
20
4
2019
medline:
25
9
2020
entrez:
20
4
2019
Statut:
ppublish
Résumé
The ability of environmental cues to trigger alcohol-seeking behaviors is believed to facilitate problematic alcohol use. We previously showed that the development of this cue-evoked alcohol approach reflects cue-alcohol learning and memory in the adult male rat; however, we do not know whether the same is true for similarly aged female rats. Consequently, adult Long-Evans female rats were allowed to drink unsweetened alcohol in the home cage (Monday, Wednesday, Friday; 24-h two-bottle choice; 5 weeks) and were subsequently split into two experimental groups: Paired and Unpaired. Groups were matched for ingested doses and alcohol bottle preference across the pre-conditioning home cage period. Both groups were trained in conditioning chambers using a Pavlovian procedure. For the Paired group, the chamber houselight was illuminated to signal access to an alcohol sipper. Houselight onset was yoked for the Unpaired group, but access to the alcohol sipper was scheduled to occur only during the intervening periods (in the absence of light). We found that in the Paired, but not Unpaired group, an alcohol approach reaction was conditioned to houselight illumination, and the level of cue-conditioned reactivity predicted drinking behavior within trials. Groups experienced equivalently low but non-negligible blood alcohol concentrations over the course of conditioning sessions. We conclude that cue-triggered alcohol-seeking behavior in adult female rats reflects associative learning about the relationship between alcohol availability and houselight illumination.
Identifiants
pubmed: 31002878
pii: S0741-8329(19)30011-4
doi: 10.1016/j.alcohol.2019.03.003
pmc: PMC6801064
mid: NIHMS1532581
pii:
doi:
Substances chimiques
Ethanol
3K9958V90M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-9Subventions
Organisme : NIAAA NIH HHS
ID : R37 AA011852
Pays : United States
Organisme : NIAAA NIH HHS
ID : T32 AA007471
Pays : United States
Organisme : CIHR
ID : MOP-137030
Pays : Canada
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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