Theoretical Importance of PVP-Alginate Hydrogels Structure on Drug Release Kinetics.
drug release
hydrogel
low field NMR
mathematical modelling
rheology
Journal
Gels (Basel, Switzerland)
ISSN: 2310-2861
Titre abrégé: Gels
Pays: Switzerland
ID NLM: 101696925
Informations de publication
Date de publication:
18 Apr 2019
18 Apr 2019
Historique:
received:
08
02
2019
revised:
25
03
2019
accepted:
04
04
2019
entrez:
21
4
2019
pubmed:
21
4
2019
medline:
21
4
2019
Statut:
epublish
Résumé
The new concepts of personalized and precision medicine require the design of more and more refined delivery systems. In this frame, hydrogels can play a very important role as they represent the best surrogate of soft living tissues for what concerns rheological properties. Thus, this paper focusses on a global theoretical approach able to describe how hydrogel polymeric networks can affect the release kinetics of drugs characterized by different sizes. The attention is focused on a case study dealing with an interpenetrated hydrogel made up by alginate and poly( Information about polymeric network characteristics (mesh size distribution and polymer volume fraction) is deduced from the theoretical interpretation of the rheological and the low field Nuclear Magnetic Resonance (NMR) characterization of hydrogels. This information is then, embodied in the mass balance equation whose resolution provides the release kinetics. Our simulations indicate the influence of network characteristics on release kinetics. In addition, the reliability of the proposed approach is supported by the comparison of the model outcome with experimental release data. This study underlines the necessity of a global theoretical approach in order to design reliable delivery systems based on hydrogels.
Sections du résumé
BACKGROUND
BACKGROUND
The new concepts of personalized and precision medicine require the design of more and more refined delivery systems. In this frame, hydrogels can play a very important role as they represent the best surrogate of soft living tissues for what concerns rheological properties. Thus, this paper focusses on a global theoretical approach able to describe how hydrogel polymeric networks can affect the release kinetics of drugs characterized by different sizes. The attention is focused on a case study dealing with an interpenetrated hydrogel made up by alginate and poly(
METHODS
METHODS
Information about polymeric network characteristics (mesh size distribution and polymer volume fraction) is deduced from the theoretical interpretation of the rheological and the low field Nuclear Magnetic Resonance (NMR) characterization of hydrogels. This information is then, embodied in the mass balance equation whose resolution provides the release kinetics.
RESULTS
RESULTS
Our simulations indicate the influence of network characteristics on release kinetics. In addition, the reliability of the proposed approach is supported by the comparison of the model outcome with experimental release data.
CONCLUSIONS
CONCLUSIONS
This study underlines the necessity of a global theoretical approach in order to design reliable delivery systems based on hydrogels.
Identifiants
pubmed: 31003517
pii: gels5020022
doi: 10.3390/gels5020022
pmc: PMC6630402
pii:
doi:
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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