Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes.

Adult Brain / diagnostic imaging Case-Control Studies Female Gene Expression Regulation Humans Male Middle Aged Nerve Net / diagnostic imaging Neural Pathways / metabolism Neuroimaging Psychotic Disorders / diagnostic imaging Schizophrenia / diagnostic imaging
Allen Human Brain Atlas dysconnectivity morphometric similarity network neuroscience psychosis

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
07 05 2019
Historique:
pubmed: 21 4 2019
medline: 17 3 2020
entrez: 21 4 2019
Statut: ppublish

Résumé

Schizophrenia has been conceived as a disorder of brain connectivity, but it is unclear how this network phenotype is related to the underlying genetics. We used morphometric similarity analysis of MRI data as a marker of interareal cortical connectivity in three prior case-control studies of psychosis: in total,

Identifiants

DOI: 10.1073/pnas.1820754116 PMID: 31004051 PMC: PMC6511038
pubmed: 31004051
pii: 1820754116
doi: 10.1073/pnas.1820754116
pmc: PMC6511038
doi:

Types de publication

Clinical Trial Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9604-9609

Subventions

Organisme : NIGMS NIH HHS
ID : P20 GM103472
Pays : United States
Organisme : Medical Research Council
ID : MR/K020706/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : NCRR NIH HHS
ID : P20 RR021938
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0801418
Pays : United Kingdom

Informations de copyright

Copyright © 2019 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

Conflict of interest statement: E.T.B. is employed half-time by the University of Cambridge and half-time by GlaxoSmithKline; he holds stock in GlaxoSmithKline.

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Auteurs

Sarah E Morgan (SE)

Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom; sem91@cam.ac.uk.
ORCID: 0000-0002-1261-5884

Jakob Seidlitz (J)

Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom.
Developmental Neurogenomics Unit, National Institute of Mental Health, Bethesda, MD 20892.

Kirstie J Whitaker (KJ)

Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom.
The Alan Turing Institute, London NW1 2DB, United Kingdom.
ORCID: 0000-0001-8498-4059

Rafael Romero-Garcia (R)

Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom.

Nicholas E Clifton (NE)

Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff CF24 4HQ, United Kingdom.
Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff CF24 4HQ, United Kingdom.

Cristina Scarpazza (C)

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.
Department of General Psychology, University of Padova, 35131 Padova, Italy.

Therese van Amelsvoort (T)

Department of Psychiatry and Neuropsychology, Maastricht University, 616 6200, Maastricht, The Netherlands.

Machteld Marcelis (M)

Department of Psychiatry and Neuropsychology, Maastricht University, 616 6200, Maastricht, The Netherlands.

Jim van Os (J)

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.
Department of Psychiatry and Neuropsychology, Maastricht University, 616 6200, Maastricht, The Netherlands.
Department of Psychiatry, University Medical Center Utrecht Brain Center, 3584 CG, Utrecht, The Netherlands.

Gary Donohoe (G)

School of Psychology, National University of Ireland Galway, Galway H91 TK33, Ireland.

David Mothersill (D)

School of Psychology, National University of Ireland Galway, Galway H91 TK33, Ireland.

Aiden Corvin (A)

Department of Psychiatry, Trinity College Dublin, Dublin 8, D08 W9RT, Ireland.

Andrew Pocklington (A)

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff CF24 4HQ, United Kingdom.
ORCID: 0000-0002-2137-0452

Armin Raznahan (A)

Developmental Neurogenomics Unit, National Institute of Mental Health, Bethesda, MD 20892.

Philip McGuire (P)

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.

Petra E Vértes (PE)

Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom.
The Alan Turing Institute, London NW1 2DB, United Kingdom.
School of Mathematical Sciences, Queen Mary University of London, London E1 4NS, United Kingdom.
ORCID: 0000-0002-0992-3210

Edward T Bullmore (ET)

Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom.
ImmunoPsychiatry, GlaxoSmithKline R&D, Stevenage SG1 2NY, United Kingdom.
ORCID: 0000-0002-8955-8283

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Cortical patterning of abnormal morphometric...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Cortical patterning of abnormal morphometric...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Cortical patterning of abnormal morphometric...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Cortical patterning of abnormal morphometric...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cortical patterning of abnormal morphometric...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Cortical patterning of abnormal morphometric...
questionsmedicales.fr › Système nerveux › Réseau nerveux › Cortical patterning of abnormal morphometric...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Cortical patterning of abnormal morphometric...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Cortical patterning of abnormal morphometric...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Troubles psychotiques › Cortical patterning of abnormal morphometric...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Cortical patterning of abnormal morphometric...