Manual for clinical language tractography.
Brain tumor surgery
Diffusion tensor imaging
Language
Neuroanatomy
Tractography
Journal
Acta neurochirurgica
ISSN: 0942-0940
Titre abrégé: Acta Neurochir (Wien)
Pays: Austria
ID NLM: 0151000
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
18
01
2019
accepted:
28
03
2019
pubmed:
21
4
2019
medline:
4
4
2020
entrez:
21
4
2019
Statut:
ppublish
Résumé
We introduce a user-friendly, standardized protocol for tractography of the major language fiber bundles. The introduced method uses dMRI images for tractography whereas the ROI definition is based on structural T1 MPRAGE MRI templates, without normalization to MNI space. ROIs for five language-relevant fiber bundles were visualized on an axial, coronal, or sagittal view of T1 MPRAGE images. The ROIs were defined based upon the tracts' obligatory pathways, derived from literature and own experiences in peritumoral tractography. The resulting guideline was evaluated for each fiber bundle in ten healthy subjects and ten patients by one expert and three raters. Overall, 300 ROIs were evaluated and compared. The targeted language fiber bundles could be tracked in 88% of the ROI pairs, based on the raters' result blinded ROI placements. The evaluation indicated that the precision of the ROIs did not relate to the varying experience of the raters. Our guideline introduces a standardized language tractography method for routine preoperative workup and for research contexts. The ROI placement guideline based on easy-to-identify anatomical landmarks proved to be user-friendly and accurate, also in inexperienced test persons.
Sections du résumé
BACKGROUND
We introduce a user-friendly, standardized protocol for tractography of the major language fiber bundles.
METHOD
The introduced method uses dMRI images for tractography whereas the ROI definition is based on structural T1 MPRAGE MRI templates, without normalization to MNI space. ROIs for five language-relevant fiber bundles were visualized on an axial, coronal, or sagittal view of T1 MPRAGE images. The ROIs were defined based upon the tracts' obligatory pathways, derived from literature and own experiences in peritumoral tractography.
RESULTS
The resulting guideline was evaluated for each fiber bundle in ten healthy subjects and ten patients by one expert and three raters. Overall, 300 ROIs were evaluated and compared. The targeted language fiber bundles could be tracked in 88% of the ROI pairs, based on the raters' result blinded ROI placements. The evaluation indicated that the precision of the ROIs did not relate to the varying experience of the raters.
CONCLUSIONS
Our guideline introduces a standardized language tractography method for routine preoperative workup and for research contexts. The ROI placement guideline based on easy-to-identify anatomical landmarks proved to be user-friendly and accurate, also in inexperienced test persons.
Identifiants
pubmed: 31004240
doi: 10.1007/s00701-019-03899-0
pii: 10.1007/s00701-019-03899-0
pmc: PMC6525736
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1125-1137Subventions
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Organisme : Humboldt-Universität zu Berlin
ID : EXC 2015/1
Pays : International
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