Expression of tetraspanins NET-6 and CD151 in breast cancer as a potential tumor biomarker.
Breast cancer
CD151
Metastasis
NET-6 (TSPAN 13)
Tetraspanin
Journal
Clinical and experimental medicine
ISSN: 1591-9528
Titre abrégé: Clin Exp Med
Pays: Italy
ID NLM: 100973405
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
23
12
2018
accepted:
12
04
2019
pubmed:
21
4
2019
medline:
26
11
2019
entrez:
21
4
2019
Statut:
ppublish
Résumé
Tetraspanins have been implicated in multiple biological functions including protein networking and cell signaling. NET-6 (TSPAN 13) has been demonstrated to be a tumor suppressor gene in breast cancer, while CD151 is more likely to act as an oncogene. However, the biological function of both proteins is still inconclusive. Immunohistochemistry was used to analyze the expression of NET-6 and CD151 proteins in breast tumors and benign epithelial cells. The cellular expression of both markers was correlated with HER2, ER, and PR status as well as tumor grade, Ki-67 scores, invasion, and metastasis. Expression of NET-6 and CD151 was variable both in tumors and in benign epithelial cells. Expression of NET-6 and CD151 was stronger in tumors than in benign epithelial cells. The expression of NET-6 was also stronger in HER2-negative, low-grade, lymphovascular invasion-negative, and non-metastatic breast tumors. There was no correlation between NET-6 expression and ER, or PR, or triple-negative status. There was no correlation between CD151 expression and HER2, ER, PR, or triple-negative status, tumor grade, or Ki-67 scores, invasion, and metastasis. The expression of tetraspanins NET-6 and CD151 may indicate an alteration of their biological function during neoplastic transformation. NET-6 expression in tumors might be a potential marker indicating the outcome of breast cancer.
Identifiants
pubmed: 31004251
doi: 10.1007/s10238-019-00554-x
pii: 10.1007/s10238-019-00554-x
doi:
Substances chimiques
Biomarkers, Tumor
0
CD151 protein, human
0
TSPAN13 protein, human
0
Tetraspanin 24
0
Tetraspanins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
377-384Subventions
Organisme : Guangxi Bureau of Science and Technology
ID : 1598013-3
Organisme : Guangxi Bureau of Science and Technology
ID : 2017GXNSFAA198043
Organisme : The Health and Family Planning Commission of Guangxi Zhuang Autonomous Region
ID : Z2015353
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