Mechanobiology of Cancer Stem Cells and Their Niche.
Mechanotransduction
Niche
Stem cells
Stiffness
Stromal remodeling
Journal
Cancer microenvironment : official journal of the International Cancer Microenvironment Society
ISSN: 1875-2292
Titre abrégé: Cancer Microenviron
Pays: Netherlands
ID NLM: 101322634
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
14
11
2018
accepted:
10
04
2019
pubmed:
21
4
2019
medline:
21
4
2019
entrez:
21
4
2019
Statut:
ppublish
Résumé
Though the existence of cancer stem cells remained enigmatic initially, over the time their participation in tumorigenesis and tumor progression has become highly evident. Today, they are also appreciated as the causal element for tumor heterogeneity and drug-resistance. Cancer stem cells activate a set of molecular pathways some of which are triggered by the unique mechanical properties of the tumor tissue stroma. A relatively new field called mechanobiology has emerged, which aims to critically evaluate the mechanical properties associated with biological events like tissue morphogenesis, cell-cell or cell-matrix interactions, cellular migration and also the development and progression of cancer. Development of more realistic model systems and biophysical instrumentation for observation and manipulation of cell-dynamics in real-time has invoked a hope for some novel therapeutic modalities against cancer in the future. This review discusses the fundamental concepts of cancer stem cells from an intriguing viewpoint of mechanobiology and some important breakthroughs to date.
Identifiants
pubmed: 31004332
doi: 10.1007/s12307-019-00222-4
pii: 10.1007/s12307-019-00222-4
pmc: PMC6529500
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
17-27Subventions
Organisme : All-India Institute of Medical Sciences
ID : A-523
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