Neural substrates of self- and external-preoccupation: A voxel-based morphometry study.
Preoccupation Scale
cerebellum
gray matter volume
magnetic resonance imaging
posterior cingulate cortex
precuneus
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
19
08
2018
revised:
20
02
2019
accepted:
01
03
2019
pubmed:
21
4
2019
medline:
1
2
2020
entrez:
21
4
2019
Statut:
ppublish
Résumé
Self- and external-preoccupation have been linked to psychopathological states. The neural substrates underlying self- and external-preoccupation remain unclear. In the present study, we aim to provide insight into the information-processing mechanisms associated with self- and external-preoccupation at the structural level. To investigate the neural substrates of self- and external-preoccupation, we acquired high-resolution T1-weighted structural images and Preoccupation Scale scores from 1,122 young subjects. Associations between regional gray matter volume (rGMV) and Preoccupation Scale subscores for self- and external-preoccupation were estimated using voxel-based morphometry. Significant positive associations between self-preoccupation and rGMV were observed in widespread brain areas such as the bilateral precuneus and posterior cingulate gyri, structures known to be associated with self-triggered self-reference during rest. Significant negative associations between external-preoccupation and rGMV were observed only in the bilateral cerebellum, regions known to be associated with behavioral addiction, sustained attention, and reward system. Our results reveal distinct neural substrates for self- and external-preoccupation at the structural level.
Identifiants
pubmed: 31004413
doi: 10.1002/brb3.1267
pmc: PMC6576210
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01267Informations de copyright
© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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