Pharmacokinetic properties of phytochemicals in Hypericum perforatum influence efficacy of regulating oxidative stress.
Antioxidant fingerprint
Bio-matching
Functional fingerprint
Medicinal plants
PCAP model
St. John's Wort
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Titre abrégé: Phytomedicine
Pays: Germany
ID NLM: 9438794
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
24
07
2018
revised:
14
11
2018
accepted:
17
11
2018
pubmed:
21
4
2019
medline:
29
8
2019
entrez:
21
4
2019
Statut:
ppublish
Résumé
Hypericum perforatum is used in ethnopharmacology and has recently become popular in conventional medicine for treatment of mild to moderate depression. The abundance of potentially functional phytochemicals and their broader utilizations in traditional medicine suggests that ingestion of H. perforatum may impart additional secondary health benefits. Considering that many phytochemicals are known to display antioxidant activity, it was hypothesized that H. perforatum ingestion may inhibit oxidative stress and inflammation (OSI) which occurs in transient cycles following exercise and consumption of meals. The aim of this study was to explore the pharmacokinetics of H. perforatum phytochemicals after ingestion to predict the absorption timing of putative medicinal phytochemicals. In silico analyses of previously published plant extract phytochemical profiles were performed, wherein the Phytochemical Absorption Prediction (PCAP) model was used to predict the pharmacokinetics of phytochemicals. The predicted times for phytochemicals to reach maximum plasma concentration (T The PCAP model identified that phytochemicals with antioxidant activity concurrently accumulate in plasma with T Based on these results it is therefore recommended that H. perforatum administration occurs 2 h before meals to provide optimal secondary health benefits associated with inhibition of postprandial stress. Additionally, these results highlight the use of in silico analyses to inform ingestion time and optimize the health benefits from ingestion of plant-based foods and medicines.
Sections du résumé
BACKGROUND
BACKGROUND
Hypericum perforatum is used in ethnopharmacology and has recently become popular in conventional medicine for treatment of mild to moderate depression. The abundance of potentially functional phytochemicals and their broader utilizations in traditional medicine suggests that ingestion of H. perforatum may impart additional secondary health benefits.
HYPOTHESIS/PURPOSE
OBJECTIVE
Considering that many phytochemicals are known to display antioxidant activity, it was hypothesized that H. perforatum ingestion may inhibit oxidative stress and inflammation (OSI) which occurs in transient cycles following exercise and consumption of meals. The aim of this study was to explore the pharmacokinetics of H. perforatum phytochemicals after ingestion to predict the absorption timing of putative medicinal phytochemicals.
STUDY DESIGN/METHODS
METHODS
In silico analyses of previously published plant extract phytochemical profiles were performed, wherein the Phytochemical Absorption Prediction (PCAP) model was used to predict the pharmacokinetics of phytochemicals. The predicted times for phytochemicals to reach maximum plasma concentration (T
RESULTS
RESULTS
The PCAP model identified that phytochemicals with antioxidant activity concurrently accumulate in plasma with T
CONCLUSION
CONCLUSIONS
Based on these results it is therefore recommended that H. perforatum administration occurs 2 h before meals to provide optimal secondary health benefits associated with inhibition of postprandial stress. Additionally, these results highlight the use of in silico analyses to inform ingestion time and optimize the health benefits from ingestion of plant-based foods and medicines.
Identifiants
pubmed: 31004882
pii: S0944-7113(18)30580-4
doi: 10.1016/j.phymed.2018.11.023
pii:
doi:
Substances chimiques
Antioxidants
0
Phytochemicals
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
152763Informations de copyright
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