Will morphing boron-based inhibitors beat the β-lactamases?
Journal
Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
19
02
2019
revised:
28
02
2019
accepted:
01
03
2019
pubmed:
21
4
2019
medline:
18
12
2019
entrez:
21
4
2019
Statut:
ppublish
Résumé
The β-lactams remain the most important antibacterials, but their use is increasingly compromised by resistance, importantly by β-lactamases. Although β-lactam and non-β-lactam inhibitors forming stable acyl-enzyme complexes with nucleophilic serine β-lactamases (SBLs) are widely used, these are increasingly susceptible to evolved SBLs and do not inhibit metallo-β-lactamases (MBLs). Boronic acids and boronate esters, especially cyclic ones, can potently inhibit both SBLs and MBLs. Vaborbactam, a monocyclic boronate, is approved for clinical use, but its β-lactamase coverage is limited. Bicyclic boronates rapidly react with SBLs and MBLs forming stable enzyme-inhibitor complexes that mimic the common anionic high-energy tetrahedral intermediates in SBL/MBL catalysis, as revealed by crystallography. The ability of boronic acids to 'morph' between sp
Identifiants
pubmed: 31004962
pii: S1367-5931(19)30035-3
doi: 10.1016/j.cbpa.2019.03.001
pmc: PMC6591701
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
beta-Lactamase Inhibitors
0
Boron
N9E3X5056Q
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-110Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S50676X/1
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-145-0004-TPG-AVISO
Pays : United Kingdom
Organisme : Cancer Research UK
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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