[Severe pneumonia and acute respiratory distress syndrome: Implication of unconventional T cells].
Pneumonies sévères et syndrome de détresse respiratoire aiguë : implication des lymphocytes T non conventionnels.
Acute respiratory distress syndrome
Lymphocytes T non conventionnels
Pneumonia
Pneumonie
Syndrome de détresse respiratoire aiguë
Unconventional T lymphocytes
Journal
Revue des maladies respiratoires
ISSN: 1776-2588
Titre abrégé: Rev Mal Respir
Pays: France
ID NLM: 8408032
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
28
02
2019
accepted:
01
03
2019
pubmed:
22
4
2019
medline:
17
1
2020
entrez:
22
4
2019
Statut:
ppublish
Résumé
Pneumonia is frequently complicated by occurrence of acute respiratory distress syndrome (ARDS), consequently to dysregulated inflammatory response. However, mechanisms driving this dysregulation are poorly understood. To address this, "unconventional T-cells (UTC)" -γδT, NKT and MAIT cells- appear to be relevant targets due to their key role in orchestrating anti-microbial immune response in the lung. Thus, using an experimental and translational approach, we test the hypothesis that a tight regulation of UTC is mandatory to fine-tune host response, and, subsequently to prevent emergence of an aberrant response leading to excessive tissue damages, and eventually, ARDS.
Identifiants
pubmed: 31005423
pii: S0761-8425(19)30086-5
doi: 10.1016/j.rmr.2019.03.007
pii:
doi:
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
451-454Informations de copyright
Copyright © 2019 SPLF. Published by Elsevier Masson SAS. All rights reserved.