MDS with 5q deletion and rare
Anemia, Macrocytic
/ complications
Biopsy
Bone Marrow
/ pathology
Chromosome Deletion
Chromosomes, Human, Pair 5
/ genetics
Hematologic Neoplasms
/ complications
Humans
Immunologic Factors
/ administration & dosage
Lenalidomide
/ administration & dosage
Male
Mastocytosis
/ complications
Middle Aged
Mutation
Myelodysplastic Syndromes
/ complications
haematology (incl blood transfusion)
malignant and benign haematology
oncology
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
20 Apr 2019
20 Apr 2019
Historique:
entrez:
22
4
2019
pubmed:
22
4
2019
medline:
4
9
2019
Statut:
epublish
Résumé
A patient with a diagnosis of myelodysplastic syndrome (MDS) with isolated 5q deletion underwent repeat bone marrow biopsy to assess haematological response after 6 months of initial lenalidomide therapy. Subsequent bone marrow biopsies revealed persistent MDS with del(5q) in addition to a small atypical mast cell population with >25% of mast cells with spindle-shaped morphology and immunohistochemistry characteristics consistent with mastocytosis. Molecular testing on the bone marrow was positive for
Identifiants
pubmed: 31005862
pii: 12/4/e227768
doi: 10.1136/bcr-2018-227768
pmc: PMC6506002
pii:
doi:
Substances chimiques
Immunologic Factors
0
Lenalidomide
F0P408N6V4
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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