Structure and Function of an Inflammatory Cytokine, Interleukin-2, Analyzed Using the Bioinformatic Approach.
Bioinformatics
Biotechnology
Interleukin 2
Interleukin 2 receptor
Signaling
Structural modeling
Journal
The protein journal
ISSN: 1875-8355
Titre abrégé: Protein J
Pays: Netherlands
ID NLM: 101212092
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
pubmed:
22
4
2019
medline:
29
4
2020
entrez:
22
4
2019
Statut:
ppublish
Résumé
The inflammatory cytokine, interleukin-2 (IL-2), is an important regulator of cellular functions. This relatively less studied member of the interleukin protein family is responsible for multiple immuno-modulatory and immuno-stimulatory tasks, like T cell activation, triggering of natural killer cells, inflammation, as well as proliferation and progression of autoimmune diseases and cancers. In this communication we report the temporally variant structural aspects of the IL-2 ligand and its receptor interfaces, based on the available crystal structures. The intended goal of this effort is to generate simulated results that could potentially aid the designs of novel structure based therapeutics.
Identifiants
pubmed: 31006082
doi: 10.1007/s10930-019-09833-8
pii: 10.1007/s10930-019-09833-8
doi:
Substances chimiques
Interleukin-2
0
Receptors, Interleukin-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
525-536Références
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