Storage, Degradation, and New Connectivity of Face-Related Semantic Memory in Alzheimer's Disease.
Alzheimer's disease
face identification
semantic memory
storage and degradation
Journal
Annals of Indian Academy of Neurology
ISSN: 0972-2327
Titre abrégé: Ann Indian Acad Neurol
Pays: India
ID NLM: 101273955
Informations de publication
Date de publication:
Historique:
entrez:
23
4
2019
pubmed:
23
4
2019
medline:
23
4
2019
Statut:
ppublish
Résumé
Excepting amnesia, impairment of other domains also hampers the activity of daily living in Alzheimer's disease (AD). Although prosopagnosia poses problem in interacting with other persons, it rarely causes problem during interaction with close relatives as known voice acts as cue for recognition. In a cohort of AD, we planned to study errors in recognition, naming, and assigning relationship of close relatives, to assess the type and frequency of errors and to explain with current knowledge and hypothesis. This cross-sectional study was conducted in Memory Clinic of Medical College Hospital, Kolkata, India, between July 2013 and June 2015. Patients were evaluated by history, general neurological examination, and neuropsychological tests. A structured questionnaire was used to assess recognition (use of honorifics) and naming defect of close relatives. AD was diagnosed in 42 patients. Prosopagnosia was found in 14 and anomia in 6 patients. Four patients exhibited problem during conversation with close relatives. They assigned name and relation of one generation earlier to close relatives with proper recognitions. We got predictive error of name and relation assignment of close relatives by one generation back with normal recognition. It can be explained by two memory traces in connection of face-visual and name (with/without relation) representation, earlier being hierarchically older and more resistant to wearing. We hypothesize that the name/relation store is orderly conserved. In AD, after degradation of part of name/relation store, a new wiring might be built up between these two traces.
Sections du résumé
BACKGROUND
BACKGROUND
Excepting amnesia, impairment of other domains also hampers the activity of daily living in Alzheimer's disease (AD). Although prosopagnosia poses problem in interacting with other persons, it rarely causes problem during interaction with close relatives as known voice acts as cue for recognition.
OBJECTIVE
OBJECTIVE
In a cohort of AD, we planned to study errors in recognition, naming, and assigning relationship of close relatives, to assess the type and frequency of errors and to explain with current knowledge and hypothesis.
MATERIALS AND METHODS
METHODS
This cross-sectional study was conducted in Memory Clinic of Medical College Hospital, Kolkata, India, between July 2013 and June 2015. Patients were evaluated by history, general neurological examination, and neuropsychological tests. A structured questionnaire was used to assess recognition (use of honorifics) and naming defect of close relatives.
RESULTS
RESULTS
AD was diagnosed in 42 patients. Prosopagnosia was found in 14 and anomia in 6 patients. Four patients exhibited problem during conversation with close relatives. They assigned name and relation of one generation earlier to close relatives with proper recognitions.
DISCUSSION
CONCLUSIONS
We got predictive error of name and relation assignment of close relatives by one generation back with normal recognition. It can be explained by two memory traces in connection of face-visual and name (with/without relation) representation, earlier being hierarchically older and more resistant to wearing.
CONCLUSIONS
CONCLUSIONS
We hypothesize that the name/relation store is orderly conserved. In AD, after degradation of part of name/relation store, a new wiring might be built up between these two traces.
Identifiants
pubmed: 31007428
doi: 10.4103/aian.AIAN_185_18
pii: AIAN-22-170
pmc: PMC6472242
doi:
Types de publication
Journal Article
Langues
eng
Pagination
170-174Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
J Cogn Neurosci. 2000 May;12(3):495-504
pubmed: 10931774
Hippocampus. 2000;10(4):352-68
pubmed: 10985275
Psychon Bull Rev. 2002 Jun;9(2):348-55
pubmed: 12120799
J Neurosci. 2003 Feb 1;23(3):986-93
pubmed: 12574428
Neuropsychologia. 1992 Apr;30(4):301-14
pubmed: 1603295
Hum Brain Mapp. 2007 Oct;28(10):967-78
pubmed: 17133390
Neuropsychologia. 2007 Sep 20;45(12):2802-10
pubmed: 17575989
Brain. 2007 Oct;130(Pt 10):2636-45
pubmed: 17898010
Nat Rev Neurosci. 2007 Dec;8(12):976-87
pubmed: 18026167
J Exp Psychol Gen. 1991 Dec;120(4):339-57
pubmed: 1837294
Annu Rev Neurosci. 2008;31:411-37
pubmed: 18558862
Trends Cogn Sci. 2011 Nov;15(11):527-36
pubmed: 22001867
Alzheimers Dement. 2013 Jan;9(1):63-75.e2
pubmed: 23305823
Am J Alzheimers Dis Other Demen. 2013 Sep;28(6):575-82
pubmed: 23823144
Brain. 1987 Oct;110 ( Pt 5):1273-96
pubmed: 3676701
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Curr Opin Neurobiol. 1997 Apr;7(2):217-27
pubmed: 9142752
J Neurosci. 1997 Jun 1;17(11):4302-11
pubmed: 9151747
J Cogn Neurosci. 1998 Jan;10(1):1-34
pubmed: 9526080